SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease
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Prof. Dr. med. Markus Sperandio

Responsibilities

Projects B01, Z03 & MGK

Contact

Institut für Kardiovaskuläre Physiologie und Pathophysiologie
Walter-Brendel-Zentrum für Experimentelle Medizin

Biomedizinisches Centrum
LMU München
Großhaderner Str. 9
82152 Planegg-Martinsried

Phone: +49 89 2180-71515
Fax: +49 89 2180-76503

10 most relevant publications:

1. Gonçalves-de-Albuquerque CF, Rohwedder I, Silva AR, Ferreira AS, Kurz ARM, Cougoule C, Klapproth S, Eggersmann T, Silva JD, de Oliveira GP, Capelozzi VL, Schlesinger GG, Costa ER, Estrela Marins RCE, Mócsai A, Maridonneau-Parini I, Walzog B, Macedo Rocco PR, Sperandio M*, de Castro-Faria-Neto HC*. (2018) The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis. Front Immunol. 9:901. *contributed equally

2. Margraf A, Nussbaum C, Rohwedder I, Klapproth S, Kurz ARM, Florian A, Wiebking V, Pircher J, Pruenster M, Immler R, Dietzel S, Kremer L, Kiefer F, Moser M, Flemmer AW, Quackenbush E, von Andrian UH, Sperandio M. (2017) Maturation of Platelet Function During Murine Fetal Development In Vivo. Arterioscler Thromb Vasc Biol. 37:1076-86.

3. Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD. (2017) Recurrent infection progressively disables host protection against intestinal inflammation. Science. 358:eaao5610.

4. Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M. (2016) MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest. 126:4125-39.

5. Pruenster M, Kurz AR, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leanderson T, Chavakis T, Roth J, Vogl T*, Sperandio M*. (2015) Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun. 6:6915. *contributed equally

6. Nussbaum C, Gloning A, Pruenster M, Frommhold D, Bierschenk S, Genzel-Boroviczeny O, von Andrian UH, Quackenbush E, Sperandio M. (2013) Neutrophil and endothelial adhesive function during human fetal ontogeny. J Leukoc Biol. 93:175-84.

7. Sperandio M, Quackenbush EJ, Sushkova N, Altstatter J, Nussbaum C, Schmid S, Pruenster M, Kurz A, Margraf A, Steppner A, Schweiger N, Borsig L, Boros I, Krajewski N, Genzel-Boroviczeny O, Jeschke U, Frommhold D, von Andrian UH. (2013) Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels. Blood. 121:e118-28.

8. Yang WH, Nussbaum C, Grewal PK, Marth JD, Sperandio M. (2012) Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. Blood. 120:1015-26.

9. Frommhold D, Kamphues A, Hepper I, Pruenster M, Lukic IK, Socher I, Zablotskaya V, Buschmann K, Lange-Sperandio B, Schymeinsky J, Ryschich E, Poeschl J, Kupatt C, Nawroth PP, Moser M, Walzog B, Bierhaus A, Sperandio M. (2010) RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood. 116:841-9.

10. Frommhold D, Ludwig A, Bixel MG, Zarbock A, Babushkina I, Weissinger M, Cauwenberghs S, Ellies LG, Marth JD, Beck-Sickinger AG, Sixt M, Lange-Sperandio B, Zernecke A, Brandt E, Weber C, Vestweber D, Ley K, Sperandio M. (2008) Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J Exp Med. 205:1435-46.


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