SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease
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Project A6 - Role of Rho-GTPases for dendritic cell migration in vivo

This project has two goals, (i) to characterize the precise functional properties and (ii) the migratory capacities of GTPase-deficient DCs.  To achieve this we will perform histological, functional and molecular analyses of GTPase-deficient DCs. In addition we plan to determine the migratory behavior of GTPase-defective DCs and LCs in cutaneous DC migration under steady-state and inflammatory conditions in situ.

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