LMU to participate in three new Priority Programs
Trafficking of immune cells is a key prerequisite for immune surveillance under physiological steady-state conditions and during disease states. Proper immune surveillance is of the utmost importance in mammalian homeostasis as it ensures defense against pathogen intruders, but also because it guarantees tissue integrity through the continuous removal of dying cells. In order to be both functional and efficient, the migration and trafficking behavior of immune cells has to be precisely controlled and fine-tuned on demand. This critical task is complicated by the fact that trafficking of immune cells does not follow a uniform course. Instead, different types of immune cells are endowed with unique machinery allowing them to follow subset-specific trafficking routes in order to fulfill their individual tasks within their individual target tissues.
To date, the molecular and cellular signatures that control and organize this complex process of mammalian immune cell trafficking are still incompletely understood. It will therefore be the mission of the SFB to dissect the signals and mechanisms that regulate the migratory responses of distinct leukocyte subsets during inflammation, development and in various infections and non-infectious disease states.
“In particular, we will make use of innovative imaging techniques, such as multiphoton microscopy, to identify selective and cell type-specific signatures of leukocyte migration,” says Professor Walzog. “As a long-term perspective, the SFB aims to contribute to the development of innovative concepts for therapeutic interventions during acute and chronic inflammatory diseases by specifically and selectively targeting the identified migratory patterns of distinct leukocyte subsets.” Researchers at the Max Planck Institute for Biochemistry in Martinsried and the Technical University of Munich, under the leadership of Professor Steffen Massberg, will also participate in the program. The scientific efforts of the SFB will be flanked by an Integrated Research Training Group on Leukocyte Trafficking, led by Professor Markus Sperandio of the Walter Brendel Center. SFB 914 is scheduled to begin on 1. July 2011, and will be funded by the DFG for four years in the first instance. The total budget for this period amounts to 9.6 million euros. (suwe/PH)
Professor Barbara Walzog
Walter Brendel Centre of Experimental Medicine at LMU
Phone: +49 (0) 89 / 2180 – 75414