SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease
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2022

  • Bromberger T, Klapproth S, Sperandio M, Moser M. (2022)
    Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation.
    Cells. 2022 May 3;11(9):1532. doi: 10.3390/cells11091532.
    PMID: 35563841 [Projects A01 and B01]
  • Lu F, Zhu L, Bromberger T, Yang J, Yang Q, Liu J, Plow EF, Moser M, Qin J. (2022)
    Mechanism of integrin activation by talin and its cooperation with kindlin.
    Nat Commun. 2022 Apr 29;13(1):2362. doi: 10.1038/s41467-022-30117-w.
    PMID: 35488005 [Project A01]
  • Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht ML, Zhang Z, Kugelmann D, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S. (2022)
    Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration.
    Blood. 2022 Apr 29:blood.2021014712. doi: 10.1182/blood.2021014712. Online ahead of print.
    PMID: 35486845 [Projects B02 and Z01]
  • Kaiser R, Escaig R, Kranich J, Hoffknecht ML, Anjum A, Polewka V, Mader M, Hu W, Belz L, Gold C, Titova A, Lorenz M, Pekayvaz K, Kääb S, Gaertner F, Stark K, Brocker T, Massberg S, Nicolai L.(2022)
    Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI.
    Blood. 2022 Apr 26:blood.2021014914. doi: 10.1182/blood.2021014914. Online ahead of print.
    PMID: 35472164 [Projects B02 and Z01]
  • Kroll J, Ruiz-Fernandez MJA, Braun MB, Merrin J, Renkawitz J. (2022)
    Quantifying the Probing and Selection of Microenvironmental Pores by Motile Immune Cells.
    Curr Protoc. 2022 Apr;2(4):e407. doi: 10.1002/cpz1.407.
    PMID: 35384410 [Project A12]
  • Ma Q, Immler R, Pruenster M, Sellmayr M, Li C, von Brunn A, von Brunn B, Ehmann RK, Wölfel R, Napoli M, Li Q, Romagnani P, Böttcher RT, Sperandio M, Anders HJ, Steiger S.(2022)
    Soluble uric acid inhibits β2 integrin-mediated neutrophil recruitment in innate immunity.
    Blood. 2022 Mar 18:blood.2021011234. doi: 10.1182/blood.2021011234. Online ahead of print.
    PMID: 35303071 [Projects A05, B01, B11 and Z03]
  • Borza CM, Bolas G, Zhang X, Browning Monroe MB, Zhang MZ, Meiler J, Skwark MJ, Harris RC, Lapierre LA, Goldenring JR, Hook M, Rivera J, Brown KL, Leitinger B, Tyska MJ, Moser M, Böttcher RT, Zent R, Pozzi A. (2022)
    The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin β1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation.
    Front Cell Dev Biol. 2022 Mar 3;10:836797. doi: 10.3389/fcell.2022.836797. eCollection 2022. PMID: 35309920 [Project A05]
  • Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deák F, Puchinger K, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wieser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hoelscher M, Massberg S, Stark K, Nicolai L. (2022)
    Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.
    Nat Commun. 2022 Feb 23;13(1):1018. doi: 10.1038/s41467-022-28508-0.
    PMID: 35197461 [Projects B02 and Z01]
  • Stutte S, Ishikawa-Ankerhold H, Lynch L, Eickhoff S, Nasiscionyte S, Guo C, van den Heuvel D, Setzensack D, Colonna M, Maier-Begandt D, Weckbach L, Brocker T, Schulz C, Walzog B, von Andrian U. (2022)
    High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue.
    J Immunol. 2022 Feb 18:ji2100022. doi: 10.4049/jimmunol.2100022. Online ahead of print.
    PMID: 35181637 [Projects A02, A06E, A10, B10 and Z01]
  • Schmidinger B, Petri K, Lettl C, Li H, Namineni S, Ishikawa-Ankerhold H, Jiménez-Soto LF, Haas R.(2022)
    Helicobacter pylori binds human Annexins via Lipopolysaccharide to interfere with Toll-like Receptor 4 signaling.
    PLoS Pathog. 2022 Feb 17;18(2):e1010326. doi: 10.1371/journal.ppat.1010326. Online ahead of print.
    PMID: 35176125 [Projects B05 and Z01]
  • Bader A, Winkelmann M, Forné I, Walzog B, Maier-Begandt D. (2022)
    Decoding the signaling profile of hematopoietic progenitor kinase 1 (HPK1) in innate immunity: a proteomic approach.
    Eur J Immunol. 2022 Jan 31. doi: 10.1002/eji.202149283. Online ahead of print.
    PMID: 35099066 [Project A02]
  • Herrero-Cervera A, Soehnlein O, Kenne E. (2022)
    Neutrophils in chronic inflammatory diseases.
    Cell Mol Immunol. 2022 Jan 17. doi: 10.1038/s41423-021-00832-3. Online ahead of print.
    PMID: 35039631 [Project B08] Review
  • Böttcher RT, Strohmeyer N, Aretz J, Fässler R. (2022)
    New insights into the phosphorylation of the threonine motif of the β1 integrin cytoplasmic domain.
    Life Sci Alliance. 2022 Jan 7;5(4):e202101301. doi: 10.26508/lsa.202101301. Print 2022 Apr.
    PMID: 34996844 [Project A05]

2021

  • Elhag S, Stremmel C, Zehrer A, Plocke J, Hennel R, Keuper M, Knabe C, Winterhalter J, Gölling V, Tomas L, Weinberger T, Fischer M, Liu L, Wagner F, Lorenz M, Stark K, Häcker H, Schmidt-Supprian M, Völker U, Jastroch M, Lauber K, Straub T, Walzog B, Hammer E, Schulz C. (2021)
    Differences in Cell-Intrinsic Inflammatory Programs of Yolk Sac and Bone Marrow Macrophages.
    Cells. 2021 Dec 17;10(12):3564. doi: 10.3390/cells10123564. PMID: 34944072 [Projects A02, A10 and B02]
  • Weckbach LT, Schweizer L, Kraechan A, Bieber S, Ishikawa-Ankerhold H, Hausleiter J, Massberg S, Straub T, Klingel K, Grabmaier U, Zwiebel M, Mann M, Schulz C; EMB Study Group (2021)
    Association of Complement and MAPK Activation With SARS-CoV-2-Associated Myocardial Inflammation.
    JAMA Cardiol. 2021 Dec 15. doi: 10.1001/jamacardio.2021.5133. Online ahead of print.
    PMID: 34910083 [Projects A10, B10 and Z01]
  • Meister S, Kellner I, Beyer S, Corradini S, Schulz C, Rogenhofer N, Keilmann L, Kolben TM, Mahner S, Kessler M, Jeschke U, Kolben T. (2021)
    Epigenetic changes occur in placentas of spontaneous and recurrent miscarriages.
    J Reprod Immunol. 2021 Dec 14;149:103466. doi: 10.1016/j.jri.2021.103466. Online ahead of print.
    PMID: 34929495 [Project A10]
  • Mittmann LA, Haring F, Schaubächer JB, Hennel R, Smiljanov B, Zuchtriegel G, Canis M, Gires O, Krombach F, Holdt L, Brandau S, Vogl T, Lauber K, Uhl B, Reichel CA. (2021)
    Uncoupled biological and chronological aging of neutrophils in cancer promotes tumor progression.
    J Immunother Cancer. 2021 Dec;9(12):e003495. doi: 10.1136/jitc-2021-003495.
    PMID: 34876407 [Projects B03 and B06E]
  • Meister S, Hahn L, Beyer S, Paul C, Mitter S, Kuhn C, von Schönfeldt V, Corradini S, Sudan K, Schulz C, Kolben TM, Mahner S, Jeschke U, Kolben T. (2021)
    Regulation of Epigenetic Modifications in the Placenta during Preeclampsia: PPARγ Influences H3K4me3 and H3K9ac in Extravillous Trophoblast Cells.
    Int J Mol Sci. 2021 Nov 18;22(22):12469. doi: 10.3390/ijms222212469.
    PMID: 34830351 [Project A10]
  • Ishikawa-Ankerhold HC, Kurzbach S, Kinali AS, Müller-Taubenberger A.(2021)
    Formation of Cytoplasmic Actin-Cofilin Rods is Triggered by Metabolic Stress and Changes in Cellular pH.
    Front Cell Dev Biol. 2021 Nov 17;9:742310. doi: 10.3389/fcell.2021.742310. eCollection 2021.
    PMID: 34869330 [Projects A07E and Z01]
  • Kübler M, Götz P, Braumandl A, Beck S, Ishikawa-Ankerhold H, Deindl E. (2021)
    Impact of C57BL/6J and SV-129 Mouse Strain Differences on Ischemia-Induced Postnatal Angiogenesis and the Associated Leukocyte Infiltration in a Murine Hindlimb Model of Ischemia.
    Int J Mol Sci. 2021 Oct 30;22(21):11795. doi: 10.3390/ijms222111795. PMID: 34769229 [Project Z01]
  • Klapproth S, Richter K, Türk C, Bock T, Bromberger T, Dominik J, Huck K, Pfaller K, Hess MW, Reichel CA, Krüger M, Nakchbandi IA, Moser M. (2021)
    Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones.
    J Cell Sci. 2021 Oct 27:jcs.259040. doi: 10.1242/jcs.259040. Online ahead of print.
    PMID: 34704600 [Projects A01 and B03]
  • Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Mühlstädt M, Boehncke WH, Weber J, Laubender D, Philippou-Massier J, Chen CS, Holtermann L, Vestweber D, Sperandio M, Schraml BU, Halin C, Dibner C, Oster H, Renkawitz J, Scheiermann C. (2021)
    Circadian clocks guide dendritic cells into skin lymphatics.
    Nat Immunol. 2021 Oct 18. doi: 10.1038/s41590-021-01040-x. Online ahead of print.
    PMID: 34663979 [Projects A12, B09E and Z03]
  • Hidalgo A, Libby P, Soehnlein O, Aramburu IV, Papayannopoulos V, Silvestre-Roig C. (2021)
    Neutrophil extracellular traps: from physiology to pathology.
    Cardiovasc Res. 2021 Oct 14:cvab329. doi: 10.1093/cvr/cvab329. Online ahead of print.
    PMID: 34648022 [Project B08]
  • Winheim E, Rinke L, Lutz K, Reischer A, Leutbecher A, Wolfram L, Rausch L, Kranich J, Wratil PR, Huber JE, Baumjohann D, Rothenfusser S, Schubert B, Hilgendorff A, Hellmuth JC, Scherer C, Muenchhoff M, von Bergwelt-Baildon M, Stark K, Straub T, Brocker T, Keppler OT, Subklewe M, Krug AB. (2021)
    Impaired function and delayed regeneration of dendritic cells in COVID-19.
    PLoS Pathog. 2021 Oct 6;17(10):e1009742. doi: 10.1371/journal.ppat.1009742. Online ahead of print.
    PMID: 34614036 [Project B02]
  • Lasch, M., Vladymyrov, M., van den Heuvel, D., Götz, P., Deindl, E., Ishikawa-Ankerhold, H. (2021)
    Multiphoton Intravital Imaging for Monitoring Leukocyte Recruitment during Arteriogenesis in a Murine Hindlimb
    Model.
    J. Vis. Exp. (175), e62969, doi:10.3791/62969 [Project Z01]
  • Zhang W, Karschnia P, von Mücke-Heim IA, Mulazzani M, Zhou X, Blobner J, Mueller N, Teske N, Dede S, Xu T, Thon N, Ishikawa-Ankerhold H, Straube A, Tonn JC, von Baumgarten L. (2021)
    In vivo two-photon characterization of tumor-associated macrophages and microglia (TAM/M) and CX3CR1 during different steps of brain metastasis formation from lung cancer.
    Neoplasia. 2021 Sep 26;23(11):1089-1100. doi: 10.1016/j.neo.2021.09.001. Online ahead of print.
    PMID: 34587566 [Project Z01]
  • Gachet-Castro C, Freitas-Castro F, Gonzales-Cordova RA, da Fonseca CK, Gomes MD, Ishikawa-Ankerhold HC
    and Baqui MMA (2021)
    Modulation of the Host Nuclear Compartment by Trypanosoma cruzi Uncovers Effects on Host Transcription
    and Splicing Machinery.
    Front. Cell. Infect. Microbiol. 11:718028. doi: 10.3389/fcimb.2021.718028 [Project Z01]
  • Nicolai L, Kaiser R, Escaig R, Hoffknecht ML, Anjum A, Leunig A, Pircher J, Ehrlich A, Lorenz M, Ishikawa-Ankerhold H, Aird WC, Massberg S, Gaertner F. (2021)
    Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains in vitro and in vivo.
    Haematologica. 2021 Sep 16. doi: 10.3324/haematol.2021.278896. Online ahead of print.
    PMID: 34525794 [Projects B02 and Z01]
  • Bader A, Gao J, Rivière T, Schmid B, Walzog B, Maier-Begandt D. (2021)
    Molecular Insights Into Neutrophil Biology From the Zebrafish Perspective: Lessons From CD18 Deficiency.
    Front Immunol. 2021 Sep 7;12:677994. doi: 10.3389/fimmu.2021.677994. eCollection 2021.
    PMID: 34557186 [Projects A02 and Z03]
  • Kübler M, Beck S, Peffenköver LL, Götz P, Ishikawa-Ankerhold H, Preissner KT, Fischer S, Lasch M, Deindl E. (2021)
    The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia.
    Int J Mol Sci. 2021 Aug 31;22(17):9484. doi: 10.3390/ijms22179484.
    PMID: 34502391 [Project Z01]
  • Bromberger T, Klapproth S, Rohwedder I, Weber J, Pick R, Mittmann L, Min-Weißenhorn SJ, Reichel CA, Scheiermann C, Sperandio M, Moser M. (2021)
    Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking.
    Front Immunol. 2021 Aug 19;12:702345. doi: 10.3389/fimmu.2021.702345. eCollection 2021.
    PMID: 34489950  [Projects A01, B01, B03, B09E and Z03]
  • Kaiser R, Leunig A, Pekayvaz K, Popp O, Joppich M, Polewka V, Escaig R, Anjum A, Hoffknecht ML, Gold C, Brambs S, Engel A, Stockhausen S, Knottenberg V, Titova A, Haji M, Scherer C, Muenchhoff M, Hellmuth JC, Saar K, Schubert B, Hilgendorff A, Schulz C, Kääb S, Zimmer R, Hübner N, Massberg S, Mertins P, Nicolai L, Stark K. (2021)
    Self-sustaining interleukin-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19.
    JCI Insight. 2021 Aug 17:150862. doi: 10.1172/jci.insight.150862. Online ahead of print.
    PMID: 34403366 [Projects B02 and Z01]
  • Pérez-Olivares L, Soehnlein O. (2021)
    Contemporary Lifestyle and Neutrophil Extracellular Traps: An Emerging Link in Atherosclerosis Disease.
    Cells. 2021 Aug 4;10(8):1985. doi: 10.3390/cells10081985.
    PMID: 34440753 Review [Project B08]
  • Frauenstein A, Ebner S, Hansen FM, Sinha A, Phulphagar K, Swatek K, Hornburg D, Mann M, Meissner F. (2021)
    Identification of covalent modifications regulating immune signaling complex composition and phenotype.
    Mol Syst Biol. 2021 Jul;17(7):e10125. doi: 10.15252/msb.202010125. PMID: 34318608 [Project A13]
  • Chen CS, Weber J, Holtkamp SJ, Ince LM, de Juan A, Wang C, Lutes L, Barnoud C, Kizil B, Hergenhan SM, Salvermoser J, Lasch M, Deindl E, Schraml B, Baumjohann D, Scheiermann C.(2021)
    Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-γ
    J Exp Med. 2021 Aug 2;218(8):e20202377. doi: 10.1084/jem.20202377. Epub 2021 Jun 4. PMID: 34086056 [Projects A11E, B09E and Z03]
  • Krishnathas GM, Strödke B, Mittmann L, Zech T, Berger LM, Reichel CA, Rösser S, Schmid T, Knapp S, Müller S, Bracher F, Fürst R, Bischoff-Kont I. (2021)
    C81-evoked inhibition of the TNFR1-NFκB pathway during inflammatory processes for stabilization of the impaired vascular endothelial barrier for leukocytes.
    FASEB J. 2021 Jun;35(6):e21656. doi: 10.1096/fj.202100037R. PMID: 34042211 [Project B03]
  • Götz P, Braumandl A, Kübler M, Kumaraswami K, Ishikawa-Ankerhold H, Lasch M, Deindl E. (2021)
    C3 Deficiency Leads to Increased Angiogenesis and Elevated Pro-Angiogenic Leukocyte Recruitment in Ischemic Muscle Tissue.
    Int J Mol Sci. 2021 May 28;22(11):5800. doi: 10.3390/ijms22115800. PMID: 34071589 [Project Z01]
  • Henneke P, Kierdorf K, Hall LJ, Sperandio M, Hornef M. (2021)
    Perinatal development of innate immune topology.
    Elife. 2021 May 25;10:e67793. doi: 10.7554/eLife.67793. PMID: 34032570 Review [Project B01]
  • Ackermann M, Anders HJ, Bilyy R, Bowlin GL, Daniel C, De Lorenzo R, Egeblad M, Henneck T, Hidalgo A, Hoffmann M, Hohberger B, Kanthi Y, Kaplan MJ, Knight JS, Knopf J, Kolaczkowska E, Kubes P, Leppkes M, Mahajan A, Manfredi AA, Maueröder C, Maugeri N, Mitroulis I, Muñoz LE, Narasaraju T, Naschberger E, Neeli I, Ng LG, Radic MZ, Ritis K, Rovere-Querini P, Schapher M, Schauer C, Simon HU, Singh J, Skendros P, Stark K, Stürzl M, van der Vlag J, Vandenabeele P, Vitkov L, von Köckritz-Blickwede M, Yanginlar C, Yousefi S, Zarbock A, Schett G, Herrmann M. (2021)
    Patients with COVID-19: in the dark-NETs of neutrophils.
    Cell Death Differ. 2021 May 24:1-15. doi: 10.1038/s41418-021-00805-z. Online ahead of print.
    PMID: 34031543 Review [Project B02]
  • Uhl B, A Mittmann L, Dominik J, Hennel R, Smiljanov B, Haring F, B Schaubächer J, Braun C, Padovan L, Pick R, Canis M, Schulz C, Mack M, Gutjahr E, Sinn P, Heil J, Steiger K, Kanse SM, Weichert W, Sperandio M, Lauber K, Krombach F, Reichel CA. (2021)
    uPA-PAI-1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils.
    EMBO Mol Med. 2021 May 16:e13110. doi: 10.15252/emmm.202013110. Online ahead of print.PMID: 33998175 [Projects B01, B03, B06E and Z03]
  • Soehnlein O, Libby P. (2021)
    Targeting inflammation in atherosclerosis - from experimental insights to the clinic.
    Nat Rev Drug Discov. 2021 May 11:1-22. doi: 10.1038/s41573-021-00198-1. Online ahead of print.
    PMID: 33976384  Review [Project B08]
  • Xia R, Loy S, Kääb S, Titova A, Schulz C, Massberg S, Clauss S. (2021)
    Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node.
    J Vis Exp. 2021 May 7;(171). doi: 10.3791/62236. PMID: 34028452 [Projects B02 and Z01]
  • Stark K, Massberg S. (2021)
    Interplay between inflammation and thrombosis in cardiovascular pathology.
    Nat Rev Cardiol. 2021 May 6:1-17. doi: 10.1038/s41569-021-00552-1. Online ahead of print.
    PMID: 33958774 Review [Projects B02 and Z01]
  • Morikis VA, Hernandez AA, Magnani JL, Sperandio M, Simon SI. (2021)
    Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients.
    Front Immunol. 2021 Apr 28;12:663886. doi: 10.3389/fimmu.2021.663886. eCollection 2021.
    PMID: 33995392 Review [Project B01]
  • Stutte S, Ruf J, Kugler I, Ishikawa-Ankerhold H, Parzefall A, Marconi P, Maeda T, Kaisho T, Krug A, Popper B, Lauterbach H, Colonna M, von Andrian U, Brocker T. (2021)
    Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice.
    Brain Behav Immun. 2021 Apr 22:S0889-1591(21)00176-8. doi: 10.1016/j.bbi.2021.04.018. Online ahead of print. PMID: 33895286 [Projects A06E and Z01]
  • Immler R, Nadolni W, Bertsch A, Morikis V, Rohwedder I, Masgrau-Alsina S, Schroll T, Yevtushenko A, Soehnlein O, Moser M, Gudermann T, Barnea ER, Rehberg M, Simon SI, Zierler S, Pruenster M, Sperandio M. (2021)
    The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation.
    Cardiovasc Res. 2021 Apr 21:cvab133. doi: 10.1093/cvr/cvab133. Online ahead of print.
    PMID: 33881519 [Projects A01, B01 and B11]
  • Matthias Kübler, Sebastian Beck, Silvia Fischer, Philipp Götz, Konda Kumaraswami, Hellen Ishikawa-Ankerhold, Manuel Lasch and Elisabeth Deindl (2021)
    Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization.
    Biomedicines 2021, 9, 395. doi: 10.3390/biomedicines9040395 [Project Z01]
  • Phulphagar K, Kühn LI, Ebner S, Frauenstein A, Swietlik JJ, Rieckmann J, Meissner F.(2021)
    Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis.
    Cell Rep. 2021 Mar 9;34(10):108826. doi: 10.1016/j.celrep.2021.108826.
    PMID: 33691121 [Project A13]
  • Nadolni W, Immler R, Hoelting K, Fraticelli M, Ripphahn M, Rothmiller S, Matsushita M, Boekhoff I, Gudermann T, Sperandio M and Zierler S. (2021)
    TRPM7 Kinase is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling.
    Front. Immunol. 11:606893. doi: 10.3389/fimmu.2020.606893 [Project B01]
  • Uhl B, Braun C, Dominik J, Luft J, Canis M, Reichel CA. (2021)
    A Novel Experimental Approach for In Vivo Analyses of the Salivary Gland Microvasculature.
    Front Immunol. 2021 Feb 17;11:604470. doi: 10.3389/fimmu.2020.604470. [Project B03]
  • Kälin RE, Cai L, Li Y, Zhao D, Zhang H, Cheng J, Zhang W, Wu Y, Eisenhut K, Janssen P, Schmitt L, Enard W, Michels F, Flüh C, Hou M, Kirchleitner SV, Siller S, Schiemann M, Andrä I, Montanez E, Giachino C, Taylor V, Synowitz M, Tonn JC, von Baumgarten L, Schulz C, Hellmann I, Glass R. (2021)
    TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression.
    Cell Syst. 2021 Feb 9:S2405-4712(21)00036-3. doi: 10.1016/j.cels.2021.01.002. Online ahead of print.
    PMID: 33592194 [Project A10]
  • Bieber S, Kraechan A, Hellmuth JC, Muenchhoff M, Scherer C, Schroeder I, Irlbeck M, Kaeaeb S, Massberg S, Hausleiter J, Grabmaier U, Orban M, Weckbach LT. (2021)
    Left and right ventricular dysfunction in patients with COVID-19-associated myocardial injury.
    Infection. 2021 Jan 30. doi: 10.1007/s15010-020-01572-8. Online ahead of print.
    PMID: 33515390 [Project B10]
  • Wichapong K, Silvestre-Roig C, Braster Q, Schumski A, Soehnlein O, Nicolaes GAF. (2021)
    Structure-based peptide design targeting intrinsically disordered proteins: Novel histone H4 and H2A peptidic inhibitors.
    Comput Struct Biotechnol J. 2021 Jan 21;19:934-948. doi: 10.1016/j.csbj.2021.01.026. eCollection 2021.
    PMID: 33598107 [Project B08]
  • Andreas Margraf, Markus Sperandio (2021)
    Leukocyte Trafficking and Hemostasis in the Mouse Fetus in vivo: A Practical Guide.
    Front Cell Dev Biol. Jan 21;8:632297. doi: 10.3389/fcell.2020.632297. eCollection 2020. Review [Projects B01 and Z03]
  • Weckbach LT, Curta A, Bieber S, Kraechan A, Brado J, Hellmuth JC, Muenchhoff M, Scherer C, Schroeder I, Irlbeck M, Maurus S, Ricke J, Klingel K, Kääb S, Orban M, Massberg S, Hausleiter J, Grabmaier U. (2021)
    Myocardial Inflammation and Dysfunction in COVID-19-Associated Myocardial Injury.
    Circ Cardiovasc Imaging. 2021 Jan;14(1):e012220. doi: 10.1161/CIRCIMAGING.120.011713. Epub 2021 Jan 19.
    PMID: 33463366 [Project B10]
  • Papaioannou NE, Salei N, Rambichler S, Ravi K, Popovic J, Küntzel V, Lehmann CHK, Fiancette R, Salvermoser J, Gajdasik DW, Mettler R, Messerer D, Carrelha J, Ohnmacht C, Haller D, Stumm R, Straub T, Jacobsen SEW, Schulz C, Withers DR, Schotta G, Dudziak D, Schraml BU. (2021)
    Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.
    Nat Commun. 2021 Jan 19;12(1):464. doi: 10.1038/s41467-020-20659-2.
    PMID: 33469015 [Projects A10 and A11E]
  • Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Alexaki VI, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, Dudeck A. (2021)
    Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation.
    Immunity. 2021 Jan 15:S1074-7613(20)30545-8. doi: 10.1016/j.immuni.2020.12.017. Online ahead of print.
    PMID: 33484643 [Project B01]
  • Wang M, Yang Y, Cansever D, Wang Y, Kantores C, Messiaen S, Moison D, Livera G, Chakarov S, Weinberger T, Stremmel C, Fijak M, Klein B, Pleuger C, Lian Z, Ma W, Liu Q, Klee K, Händler K, Ulas T, Schlitzer A, Schultze JL, Becher B, Greter M, Liu Z, Ginhoux F, Epelman S, Schulz C, Meinhardt A, Bhushan S. (2021)
    Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis.
    Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2013686117. doi: 10.1073/pnas.2013686117. PMID: 33372158. [Project A10]

2020

  • Xia R, Vlcek J, Bauer J, Kääb S, Ishikawa-Ankerhold H, van den Heuvel DA, Schulz C, Massberg S, Clauss S. (2020)
    Whole-Mount Immunofluorescence Staining, Confocal Imaging and 3D Reconstruction of the Sinoatrial and Atrioventricular Node in the Mouse.
    J Vis Exp. 2020 Dec 22;(166). doi: 10.3791/62058. PMID: 33427243 [Projects A10 and Z01]
  • Immler R, Lange-Sperandio B, Steffen T, Beck H, Rohwedder I, Roth J, Napoli M, Hupel G, Pfister F, Popper B, Uhl B, Mannell H, Reichel CA, Vielhauer V, Scherberich J, Sperandio M, Pruenster M. (2020)
    Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo.
    Front Immunol. 2020 Dec 22;11:588245. doi: 10.3389/fimmu.2020.588245. eCollection 2020. PMID: 33414784 [Projects B01, B03 and B11]
  • Orosz A, Walzog B, Mócsai A. (2020).
    In Vivo Functions of Mouse Neutrophils Derived from HoxB8-Transduced Conditionally Immortalized Myeloid Progenitors.
    J Immunol. 2020 Dec 11:ji2000807. doi: 10.4049/jimmunol.2000807. Online ahead of print.
    PMID: 33310871 [Project A02]
  • Nicolai L, Schiefelbein K, Lipsky S, Leunig A, Hoffknecht M, Pekayvaz K, Raude B, Marx C, Ehrlich A, Pircher J, Zhang Z, Saleh I, Marel AK, Löf A, Petzold T, Lorenz M, Stark K, Pick R, Rosenberger G, Weckbach L, Uhl B, Xia S, Reichel CA, Walzog B, Schulz C, Zheden V, Bender M, Li R, Massberg S, Gaertner F. (2020).
    Vascular surveillance by haptotactic blood platelets in inflammation and infection.
    Nat Commun. 2020 Nov 13;11(1):5778. doi: 10.1038/s41467-020-19515-0. PMID: 33188196 [Projects A02, A10, B02, B03, B10, Z01 and Z03]
  • Lasch M, Kumaraswami K, Nasiscionyte S, Kircher S, van den Heuvel D, Meister S, Ishikawa-Ankerhold H, Deindl E. (2020).
    RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue. .
    Front Physiol. 2020 Nov 6;11:576736. doi: 10.3389/fphys.2020.576736. eCollection 2020. PMID: 33240100 [Project Z01]
  • Schulz C, Petzold T, Ishikawa-Ankerhold H. (2020).
    Macrophage regulation of granulopoiesis and neutrophil functions.
    Antioxid Redox Signal. 2020 Oct 27. doi: 10.1089/ars.2020.8203. Online ahead of print. PMID: 33107319 Review [Projects A10 and Z01]
  • Rivière T, Bader A, Pogoda K, Walzog B, Maier-Begandt D. (2020).
    Structure and Emerging Functions of LRCH Proteins in Leukocyte Biology.
    Front Cell Dev Biol. 2020 Sep 22;8:584134. doi: 10.3389/fcell.2020.584134. eCollection 2020. PMID: 33072765 Review [Project A02]
  • Weinberger T, Esfandyari D, Messerer D, Percin G, Schleifer C, Thaler R, Liu L, Stremmel C, Schneider V, Vagnozzi RJ, Schwanenkamp J, Fischer M, Busch K, Klapproth K, Ishikawa-Ankerhold H, Klösges L, Titova A, Molkentin JD, Kobayashi Y, Engelhardt S, Massberg S, Waskow C, Perdiguero EG, Schulz C. (2020).
    Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation.
    Nat Commun. 2020 Sep 11;11(1):4549. doi: 10.1038/s41467-020-18287-x. PMID: 32917889 [Projects A10, B02 and Z01]
  • Ernst A, Hennel R, Krombach J, Kapfhammer H, Brix N, Zuchtriegel G, Uhl B, Reichel CA, Frey B, Gaipl US, Winssinger N, Shirasawa S, Sasazuki T, Sperandio M, Belka C, Lauber K. (2020).
    Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.
    Front Oncol. 2020 Aug 27;10:1668. doi: 10.3389/fonc.2020.01668. eCollection 2020.PMID: 32984042 [Projects B01, B03 and B06E]
  • Samarelli AV, Ziegler T, Meves A, Fässler R, Böttcher RT (2020).
    Rabgap1 promotes recycling of active β1 integrins to support effective cell migration.
    J Cell Sci. 2020 Aug 25:jcs.243683. doi: 10.1242/jcs.243683. PMID: 32843574 [Online ahead of print] [Project A05]
  • Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, Muenchhoff M, Hellmuth JC, Ledderose S, Schulz H, Scherer C, Rudelius M, Zoller M, Höchter D, Keppler O, Teupser D, Zwißler B, Bergwelt-Baildon M, Kääb S, Massberg S, Pekayvaz K, Stark K. (2020).
    Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy.
    Circulation. 2020 Jul 28. doi: 10.1161/CIRCULATIONAHA.120.048488. [Online ahead of print].
    [Projects B02 and Z01]
  • Werner AC, Weckbach LT, Salvermoser M, Pitter B, Cao J, Maier-Begandt D, Forné I, Schnittler HJ, Walzog B, Montanez E. (2020).
    Coronin 1B controls endothelial actin dynamics at cell-cell junctions and is required for vessel network assembly
    Front. Cell Dev. Biol. July 31, 2020 doi:10.3389/fcell.2020.00708 [Online ahead of print] [Projects A02 and B10]
  • Zuchtriegel G, Uhl B, Pick R, Ramsauer M, Dominik J, Mittmann LA, Canis M, Kanse S, Sperandio M, Krombach F, Reichel CA. (2020).
    Vitronectin stabilizes intravascular adhesion of neutrophils by coordinating beta2 integrin clustering.
    Haematologica. 2020 Jul 23:haematol.2019.226241. doi: 10.3324/haematol.2019.226241. [Online ahead of print]  [Projects B03, B01 and Z03]
  • Kameritsch P, Renkawitz J. (2020)
    Principles of Leukocyte Migration Strategies.
    Trends Cell Biol. 2020 Jul 17:S0962-8924(20)30125-2. doi: 10.1016/j.tcb.2020.06.007. [Online ahead of print]. Review [Project A12]
  • Zernecke A, Winkels H, Cochain C, Williams JW, Wolf D, Soehnlein O, Robbins CS, Monaco C, Park I, McNamara CA, Binder CJ, Cybulsky MI, Scipione CA, Hedrick CC, Galkina EV, Kyaw T, Ghosheh Y, Dinh HQ, Ley K. (2020).
    Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
    Circ Res. 2020 Jul 17;127(3):402-426. doi: 10.1161/CIRCRESAHA.120.316903. [Epub ahead of print] Review [Project B08]
  • Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M. (2020).
    Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
    Circ Res. 2020 Jun 17. doi: 10.1161/CIRCRESAHA.120.316743. [Epub ahead of print] [Project B08]
  • Pacheco-Fernandez N, Pakdel M, Blank B, Sanchez-Gonzalez I, Weber K, Tran ML, Hecht TK, Gautsch R, Beck G, Perez F, Hausser A, Linder S, von Blume J. (2020).
    Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs.
    J Cell Biol. 2020 Aug 3;219(8). pii: e201907058. doi: 10.1083/jcb.201907058. [Project A09]
  • Fischer W, Haas R. (2020).
    Different roles of integrin-β1 and integrin-αv for type IV secretion of CagA versus cell elongation phenotype and cell lifting by Helicobacter pylori.
    PLoS Pathog. 2020 Jun 4;16(6):e1008564. doi: 10.1371/journal.ppat.1008564. eCollection 2020 Jun. Formal Comment [Project B05]
  • Zhou X, Mulazzani M, von Mücke-Heim IA, Langer S, Zhang W, Ishikawa-Ankerhold H, Dreyling M, Straube A, von Baumgarten L. (2020).
    The Role of BAFF-R Signaling in the Growth of Primary Central Nervous System Lymphoma.
    Front Oncol. 2020 May 27;10:682. doi: 10.3389/fonc.2020.00682. eCollection 2020. [Project Z01]
  • Ortega-Gomez A, Soehnlein O. (2020).
    Lack of Proteinase 3 Stabilizes Advanced Atherosclerotic Lesions.
    Thromb Haemost. 2020 May 13. doi: 10.1055/s-0040-1710316. [Epub ahead of print] [Project B08]
  • Döring Y, Libby P, Soehnlein O. (2020).
    Neutrophil Extracellular Traps Participate in Cardiovascular Diseases: Recent Experimental and Clinical Insights.
    Circ Res. 2020 Apr 24;126(9):1228-1241. doi: 10.1161/CIRCRESAHA.120.315931. [Epub 2020 Apr 23]. Review [Project B08]
  • Masgrau-Alsina S, Sperandio M, Rohwedder I. (2020).
    Neutrophil recruitment and intracellular vesicle transport: a short overview.
    Eur J Clin Invest. 2020 Apr 14. doi: 10.1111/eci.13237. [Epub ahead of print]Review[Project B01]
  • Wolbert J, Li X, Heming M, Mausberg AK, Akkermann D, Frydrychowicz C, Fledrich R, Groeneweg L, Schulz C, Stettner M, Alonso Gonzalez N, Wiendl H, Stassart R, Meyer Zu Hörste G. (2020).
    Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity.
    Proc Natl Acad Sci U S A. 2020 Apr 15. pii: 201912139. doi: 10.1073/pnas.1912139117. [Epub ahead of print][Project A10]
  • Fischer-Riepe L, Daber N, Schulte-Schrepping J, Véras De Carvalho BC, Russo A, Pohlen M, Fischer J, Chasan AI, Wolf M, Ulas T, Glander S, Schulz C, Skryabin B, Wollbrink A, Steingraeber N, Stremmel C, Koehle M, Gärtner F, Vettorazzi S, Holzinger D, Gross J, Rosenbauer F, Stoll M, Niemann S, Tuckermann J, Schultze JL, Roth J, Barczyk-Kahlert K. (2020).
    CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow.
    J Allergy Clin Immunol. 2020 Mar 18. pii: S0091-6749(20)30344-4. doi: 10.1016/j.jaci.2020.02.034. [Epub ahead of print] [Project A10]
  • Natallia Salei, Stephan Rambichler, Johanna Salvermoser, Nikos E. Papaioannou, Ronja Schuchert, Dalia Pakalniškytė, Na Li, Julian A. Marschner, Julia Lichtnekert, Christopher Stremmel, Filippo M. Cernilogar, Melanie Salvermoser, Barbara Walzog, Tobias Straub, Gunnar Schotta, Hans-Joachim Anders, Christian Schulz and Barbara U. Schraml (2020).
    The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties
    J Am Soc Nephrol. 2020 Feb;31(2):257-278. doi: 10.1681/ASN.2019040419. PMID: 31932472 [Projects A11, A02, A10]
  • Eckardt V, Miller MC, Blanchet X, Duan R, Leberzammer J, Duchene J, Soehnlein O, Megens RT, Ludwig AK, Dregni A, Faussner A, Wichapong K, Ippel H, Dijkgraaf I, Kaltner H, Döring Y, Bidzhekov K, Hackeng TM, Weber C, Gabius HJ, von Hundelshausen P, Mayo KH (2020).
    Chemokines and galectins form heterodimers to modulate inflammation.
    EMBO Rep. 2020 Feb 21:e47852. doi: 10.15252/embr.201947852. [Epub ahead of print] [Project B08]
  • Schmidt A, Huber JE, Sercan Alp Ö, Gürkov R, Reichel CA, Herrmann M, Keppler OT, Leeuw T, Baumjohann D. (2020)
    Complex human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on germinal center T and B cells.
    EBioMedicine. 2020 Feb 27;53:102684. doi: 10.1016/j.ebiom.2020.102684[Project B03]
  • Behrens IK, Busch B, Ishikawa-Ankerhold H, Palamides P, Shively JE, Stanners C, Chan C, Leung N, Gray-Owen S, Haas R. (2020)
    The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils.
    mBio. 2020 Feb 4;11(1) [Projects B05 and Z01]
  • Tanzer MC, Frauenstein A, Stafford CA, Phulphagar K, Mann M, Meissner F. (2020).
    Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death.
    Cell Rep. 2020 Jan 28;30(4):1260-1270.e5. doi: 10.1016/j.celrep.2019.12.079. PMID: 31995763 [Project A13]
  • Ziogas A, Maekawa T, Wiessner JR, Le TT, Sprott D, Troullinaki M, Neuwirth A, Anastasopoulou V, Grossklaus S, Chung KJ, Sperandio M, Chavakis T, Hajishengallis G, Alexaki VI. (2020)
    DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1.
    J Immunol. 2020 Jan 24. pii: ji1900746. doi: 10.4049/jimmunol.1900746. [Epub ahead of print]. [Project B01]
  • Németh T, Sperandio M, Mócsai A.(2020)
    Neutrophils as emerging therapeutic targets.
    Nat Rev Drug Discov. 2020 Jan 22. doi: 10.1038/s41573-019-0054-z. [Epub ahead of print].Review [Project B01]
  • Nicolai L, Massberg S. (2020)
    Platelets as key players in inflammation and infection
    Curr Opin Hematol. Vol 27 (1) January 2020 pg. 34-40. Review [Projects B02 and Z01]

 2019

  • Puhr-Westerheide D, Schink SJ, Fabritius M, Mittmann L, Hessenauer MET, Pircher J, Zuchtriegel G, Uhl B, Holzer M, Massberg S, Krombach F, Reichel CA (2019)
    Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation.
    Sci Rep. 2019 Nov 4;9(1):15932. doi: 10.1038/s41598-019-52041-8. [Project B03]
  • Hellen C. Ishikawa-Ankerhold and Annette Müller-Taubenberger (2019)
    Actin assembly states in Dictyostelium discoideum at different stages of development and during cellular stress.
    Int. J. Dev. Biol. 63: 417-427 (2019). Review [Projects Z01 and A07E]
  • Matthias Mulazzania, Simon P. Fräßle, Iven von Mücke-Heim, Sigrid Langer, Xiaolan Zhou, Hellen Ishikawa-Ankerhold, Justin Leube, Wenlong Zhang, Sarah Dötsch, Mortimer Svec, Martina Rudelius, Martin Dreyling, Michael von Bergwelt-Baildon, Andreas Straube, Veit R. Buchholz, Dirk H. Busch and Louisa von Baumgarten (2019)
    Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice
    Proc Natl Acad Sci U S A. 2019 Nov 11. pii: 201903854. doi: 10.1073/pnas.1903854116. [Epub ahead of print][Project Z01]
  • Rohwedder I, Kurz ARM, Pruenster M, Immler R, Pick R, Eggersmann T, Klapproth S, Johnson JL, Masgrau Alsina S, Lowell CA, Mócsai A, Catz SD, Sperandio M. (2019)
    Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration.
    Haematologica. 2019 Nov 7 [Epub ahead of print] [Projects B01 and Z03]
  • Bromberger T, Zhu L, Klapproth S, Qin J, Moser M. (2019)
    Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation.
    J Cell Sci. 2019 Nov 1;132(21). pii: jcs235531. doi: 10.1242/jcs.235531 [Project A01]
  • Nicolai L, Gaertner F, Massberg S. (2019)
    Platelets in Host Defense: Experimental andClinical Insights.
    Trends Immunol. 2019 Volume 40, Issue 10, October 2019 Pages 922-938. Review. [Projects B02 and Z01]
  • Ludwig T. Weckbach, Andreas Uhl, Felicitas Boehm, Valentina Seitelberger, Bruno C. Huber, Gabriela Kania, Stefan Brunner and Ulrich Grabmaier (2019)
    Blocking LFA-1 Aggravates Cardiac Inflammation in Experimental Autoimmune Myocarditis.
    Cells. 2019 Oct 17;8(10). pii: E1267. doi: 10.3390/cells8101267 [Project B10]
  • Klapproth S, Bromberger T, Türk C, Krüger M, Moser M. (2019)
    A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability.
    J Cell Biol. 2019 Sep 19. pii: jcb.201903109. doi: 10.1083/jcb.201903109. [Epub ahead of print] [Project A01]
  • Marx C, Novotny J, Salbeck D, Zellner KR, Nicolai L, Pekayvaz K, Kilani B, Stockhausen S, Bürgener N, Kupka D, Stocker TJ, Weckbach LT, Pircher J, Moser M, Joner M, Desmet W, Adriaenssens T, Neumann FJ, Gershlick AH, Ten Berg JM, Lorenz M, Stark K. (2019)
    Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps.
    Blood. 2019 Sep 3. pii: blood.2019000518. doi: 10.1182/blood.2019000518. [Epub ahead of print][Projects B02 and A01]
  • de Juan A, Ince LM, Pick R, Chen CS, Molica F, Zuchtriegel G, Wang C, Zhang D, Druzd D, Hessenauer MET, Pelli G, Kolbe I, Oster H, Prophete C, Hergenhan SM, Albrecht U, Ripperger J, Montanez E, Reichel CA, Soehnlein O, Kwak BR, Frenette PS, Scheiermann C. (2019)
    Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins.
    Circulation. 2019 Aug 12. doi: 10.1161/CIRCULATIONAHA.119.040232. [Epub ahead of print][Projects B09, B08 and B03]
  • von Blume J, Hausser A. (2019)
    Lipid-dependent coupling of secretory cargo sorting and trafficking at the trans-Golgi network.
    FEBS Lett. 2019 Jul 25. doi: 10.1002/1873-3468.13552. [Epub ahead of print] Review [Project A09]
  • Pircher J, Engelmann B, Massberg S, Schulz C. (2019)
    Platelet-Neutrophil Crosstalk in Atherothrombosis.
    Thromb Haemost. 2019 Jun 29. doi: 10.1055/s-0039-1692983. [Epub ahead of print] [Project A10 and B02]
  • Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola JR, de Jong R, Bongiovanni D, Bozoglu T, Maas SL, D'Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager HB, Döring Y, Nahrendorf M, Kupatt C, Soehnlein O. (2019)
    Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair.
    J Am Coll Cardiol. 2019 Jun 18;73(23):2990-3002. [Project B08]
  • Pick R, He W, Chen CS, Scheiermann C. (2019)
    Time-of-Day-Dependent Trafficking and Function of Leukocyte Subsets.
    Trends Immunol. 2019 Jun;40(6):524-537. [Epub 2019 May 17]. Review [Projects B09 and Z03]
  • Cassatella MA, Östberg NK, Tamassia N, Soehnlein O. (2019)
    Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines.
    Trends Immunol. 2019 May 30. [Epub ahead of print]. Review [Project B08]
  • Guenther C, Faisal I, Uotila LM, Asens ML, Harjunpää H, Savinko T, Öhman T, Yao S, Moser M, Morris SW, Tojkander S, Fagerholm SC. (2019)
    A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation.
    Front Immunol. 2019 May 28;10:1138. eCollection 2019. [Project A01]
  • Cassatella MA, Östberg NK, Tamassia N, Soehnlein O. (2019)
    Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines.
    Trends Immunol. 2019 May 30. pii: S1471-4906(19)30105-X. doi: 10.1016/j.it.2019.05.003. [Epub ahead of print] Review. [Project B08]
  • Soehnlein O. (2019)
    Neutrophil Research, Quo Vadis?
    Trends Immunol. 2019 May 24. pii: S1471-4906(19)30100-0. [Epub ahead of print] [Project B08]
  • Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. (2019)
    Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
    Nature. 2019 May 1. [Epub ahead of print] [Project B08]
  • Clauss S, Bleyer C, Schüttler D, Tomsits P, Renner S, Klymiuk N, Wakili R, Massberg S, Wolf E, Kääb S. (2019)
    Animal models of arrhythmia: classic electrophysiology to genetically modified large animals.
    Nat Rev Cardiol. 2019 Mar 20. [Epub ahead of print] Review. [Project B02]
  • Ye Y, Kuhn C, Kösters M, Arnold GJ, Ishikawa-Ankerhold H, Schulz C, Rogenhofer N, Thaler CJ, Mahner S, Fröhlich T, Jeschke U, von Schönfeldt V. (2019)
    Anti α-enolase antibody is a novel autoimmune biomarker for unexplained recurrent miscarriages.
    EBioMedicine. 2019 Feb 28. pii: S2352-3964(19)30104-5. [Epub ahead of print] [Projects A10 and Z01]
  • Cremer S, Michalik KM, Fischer A, Pfisterer L, Jaé N, Winter C, Boon RA, Muhly-Reinholz M, John D, Uchida S, Weber C, Poller W, Günther S, Braun T, Li DY, Maegdefessel L, Matic Perisic L, Hedin U, Soehnlein O, Zeiher A, Dimmeler S. (2019)
    Hematopoietic Deficiency of the Long Non-Coding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation.
    Circulation. 139(10):1320-1334. [Project B08]
  • Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, Germain RN, Sahai E, Klauschen F, Reis E Sousa C. (2019)
    Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors.
    Sci Immunol. 4(33). [Project A11]
  • Margraf A, Nussbaum C, Sperandio M. (2019)
    Ontogeny of platelet function.
    Blood Adv. 3(4):692-703. Review. [Project B01]
  • Zwick M, Ulas T, Cho YL, Ried C, Grosse L, Simon C, Bernhard C, Busch DH, Schultze JL, Buchholz VR, Stutte S, Brocker T. (2019)
    Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
    Front Immunol. 10:222. [Project A06]
  • Van Avondt K, Maegdefessel L, Soehnlein O. (2019)
    Therapeutic Targeting of Neutrophil Extracellular Traps in Atherogenic Inflammation.
    Thromb Haemost. 2019 Feb 7. [Epub ahead of print][Project B08]
  • Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossío I, Lechuga-Vieco AV, García-Prieto J, Gómez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, López J, Bidzhekov K, Bachelerie F, Abad-Santos F, Muñoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibáñez B, Hidalgo A. (2019)
    A Neutrophil Timer Coordinates Immune Defense and Vascular Protection.
    Immunity. 50(2):390-402.e10. [Project B08]
  • Batsios P, Ishikawa-Ankerhold HC, Roth H, Schleicher M, Wong CCL, Müller-Taubenberger A. (2019)
    Ate1-mediated post-translational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum.
    Mol Biol Cell. 30(4):453-466. [Projects A07E and Z01]
  • Weckbach LT, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer A, Pick R, Salvermoser M, Czermak T, Pircher J, Sorrelle N, Migliorini M, Strickland DK, Klingel K, Brinkmann V, Abu Abed U, Eriksson U, Massberg S, Brunner S, Walzog B. (2019)
    Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
    J Exp Med. 216(2):350-368. [Projects A02, B02 and Z03]
  • Ince LM, Weber J, Scheiermann C. (2019)
    Control of Leukocyte Trafficking by Stress-Associated Hormones.
    Front Immunol. 9:3143. Review. [Project B09]
  • Grabowski P, Hesse S, Hollizeck S, Rohlfs M, Behrends U, Sherkat R, Tamary H, Unal E, Somech R, Patiroglu T, Canzar S, van der Werff Ten Bosch J, Klein C, Rappsilber J. (2019)
    Proteome analysis of human neutrophil granulocytes from patients with monogenic disease using data-independent acquisition.
    Mol Cell Proteomics. 2019 Jan 10. [Epub ahead of print][Project A08]
  • Papaioannou NE, Pasztoi M, Schraml BU. (2019)
    Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?
    Front Immunol. 9:3123. Review. [Project A11]

2018

  • Bromberger T, Klapproth S, Rohwedder I, Zhu L, Mittmann L, Reichel CA, Sperandio M, Qin J, Moser M. (2018)
    Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice.
    Blood. 132(26):2754-2762. [Projects A01, B01 and B03]
  • He W, Holtkamp S, Hergenhan SM, Kraus K, de Juan A, Weber J, Bradfield P, Grenier JMP, Pelletier J, Druzd D, Chen CS, Ince LM, Bierschenk S, Pick R, Sperandio M, Aurrand-Lions M, Scheiermann C. (2018)
    Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues.
    Immunity. 49(6):1175-1190.e7. [Projects B01, B09 and Z03]
  • Maas SL, Soehnlein O, Viola JR. (2018)
    Organ-Specific Mechanisms of Transendothelial Neutrophil Migration in the Lung, Liver, Kidney, and Aorta.
    Front Immunol. 9:2739. [Project B08]
  • Salvermoser M, Begandt D, Alon R, Walzog B. (2018)
    Nuclear Deformation During Neutrophil Migration at Sites of Inflammation.
    Front Immunol. 9:2680. [Project A02]
  • Medeiros-de-Moraes IM, Gonçalves-de-Albuquerque CF, Kurz ARM, Oliveira FMJ, de Abreu VHP, Torres RC, Carvalho VF, Estato V, Bozza PT, Sperandio M, de Castro-Faria-Neto HC, Silva AR. (2018)
    Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis.
    Oxid Med Cell Longev. 2018:6053492. [Project B01]
  • Krombach J, Hennel R, Brix N, Orth M, Schoetz U, Ernst A, Schuster J, Zuchtriegel G, Reichel CA, Bierschenk S, Sperandio M, Vogl T, Unkel S, Belka C, Lauber K. (2018)
    Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells.
    Oncoimmunology. 8(1):e1523097. [Projects B01, B03 and B06E]
  • Stocker TJ, Pircher J, Skenderi A, Ehrlich A, Eberle C, Megens RTA, Petzold T, Zhang Z, Walzog B, Müller-Taubenberger A, Weber C, Massberg S, Ishikawa-Ankerhold H, Schulz C. (2018)
    The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis.
    Thromb Haemost. 118(12):2098-2111.
    [Projects A10, A02, A07E and Z01]
  • Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT. (2018)
    LCP1 preferentially binds clasped aMß2 integrin and attenuates leukocyte adhesion under flow.
    J Cell Sci. 131(22). [Projects A05 and B01]
  • Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A. (2018)
    Neutrophils instruct homeostatic and pathological states in naive tissues.
    J Exp Med. 215(11):2778-2795. [Project B08]
  • Deng Y, Pakdel M, Blank B, Sundberg EL, Burd CG, von Blume J. (2018)
    Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network.
    Dev Cell. 47(4):464-478.e8. [Project A09]
  • Meinhardt A, Wang M, Schulz C, Bhushan S. (2018)
    Microenvironmental signals govern the cellular identity of testicular macrophages.
    J Leukoc Biol. 104:757-66. [Project A10]
  • Zhao Q, Busch B, Jiménez-Soto LF, Ishikawa-Ankerhold H, Massberg S, Terradot L, Fischer W, Haas R. (2018)
    Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation.
    PLoS Pathog. 14(10):e1007359. [Projects B05 and Z01]
  • Hessenauer MET, Lauber K, Zuchtriegel G, Uhl B, Hussain T, Canis M, Strieth S, Berghaus A, Reichel CA. (2018)
    Vitronectin promotes the vascularization of porous polyethylene biomaterials.
    Acta Biomater. 82:24-33 [Project B03]
  • Zehrer A, Pick R, Salvermoser M, Boda A, Miller M, Stark K, T Weckbach L, Walzog B, Begandt D. (2018)
    A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity.
    J Immunol. 201(6):1748-1764. [Projects A02, B02 and Z03]
  • Pfeiler S, Thakur M, Grünauer P, Megens RTA, Joshi U, Coletti R, Samara V, Müller-Stoy G, Ishikawa-Ankerhold H, Stark K, Klingl A, Fröhlich T, Arnold GJ, Wörmann S, Bruns CJ, Algül H, Weber C, Massberg S, Engelmann B. (2018)
    CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis.
    FASEB J. 2018 Sep 12 [Epub ahead of print] [Project Z01]
  • Moretti FA, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, Scheiermann C, Sperandio M, Fässler R, Moser M. (2018)
    Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
    Elife. 7. pii: e35816. [Projects A01, A05, B01, B09 and Z03]
  • Kurz ARM, Catz SD, Sperandio M. (2018)
    Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.
    Trends Immunol. 39(8):656-669 [Review, project B01]
  • Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M, Hristov M, Zeller T, Nicolaes GAF, Weber C, Viola JR, Hidalgo A, Scheiermann C, Soehnlein O. (2018)
    Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis.
    Cell Metab. 28(1):175-182 [Projects B01, B09 and B08]
  • Bonsor DA, Zhao Q, Schmidinger B, Weiss E, Wang J, Deredge D, Beadenkopf R, Dow B, Fischer W, Beckett D, Wintrode PL, Haas R, Sundberg EJ. (2018)
    The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA.
    EMBO J. 37(13) [Project B05]
  • Thome S, Begandt D, Pick R, Salvermoser M, Walzog B. (2018)
    Intracellular ß(2) integrin (CD11/CD18) interacting partners in neutrophil trafficking. 
    Eur J Clin Invest. 48 Suppl 2:e12966. [Review, projects A02 and Z03]
  • Immler R, Simon SI, Sperandio M. (2018)
    Calcium signaling and related ion channels in neutrophil recruitment and function.
    Eur J Clin Invest. 48 Suppl 2:e12964. [Review, project B01]
  • Pircher J, Czermak T, Ehrlich A, Eberle C, Gaitzsch E, Margraf A, Grommes J, Saha P, Titova A, Ishikawa-Ankerhold H, Stark K, Petzold T, Stocker T, Weckbach LT, Novotny J, Sperandio M, Nieswandt B, Smith A, Mannell H, Walzog B, Horst D, Soehnlein O, Massberg S, Schulz C. (2018)
    Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation.
    Nat Commun. 9(1):1523. [Projects B02, B01, A02, B08, Z01 and A10]
  • Rami M, Guillamat-Prats R, Rinne P, Salvermoser M, Ring L, Bianchini M, Blanchet X, Megens RTA, Döring Y, Walzog B, Soehnlein O, Weber C, Faussner A, Steffens S. (2018)
    Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis.
    Arterioscler Thromb Vasc Biol. 38(5):1007-1019 [Project A02]
  • Stremmel C, Schuchert R, Schneider V, Weinberger T, Thaler R, Messerer D, Helmer S, Geissmann F, Frampton J, Massberg S, Schulz C. (2018)
    Inducible disruption of the c-myb gene allows allogeneic bone marrow transplantation without irradiation.
    J Immunol Methods. 457:66-72 [Project A10]
  • Salvermoser M, Pick R, Weckbach LT, Zehrer A, Loehr P, Drechsler M, Sperandio M, Soehnlein O, Walzog B. (2018)
    Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation.
    Blood. 131(17):1887-1898 [Projects A02, B01, B08 and Z03]
  • Gonçalves-de-Albuquerque CF, Rohwedder I, Silva AR, Ferreira AS, Kurz ARM, Cougoule C, Klapproth S, Eggersmann T, Silva JD, de Oliveira GP, Capelozzi VL, Schlesinger GG, Costa ER, Estrela Marins RCE, Mócsai A, Maridonneau-Parini I, Walzog B, Macedo Rocco PR, Sperandio M, de Castro-Faria-Neto HC. (2018)
    The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis.
    Front Immunol. 9:901. [Projects A02 and B01]
  • Salvermoser J, van Blijswijk J, Papaioannou NE, Rambichler S, Pasztoi M, Pakalniškyte D, Rogers NC, Keppler SJ, Straub T, Reis E Sousa C, Schraml BU. (2018)
    Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo.
    Front Immunol. 9:699 [Project A11]
  • Scheiermann C, Gibbs J, Ince L, Loudon A. (2018)
    Clocking in to immunity.
    Nat Rev Immunol. 18(7):423-437 [Review, Projects B09 and Z03]
  • Stark K, Schubert I, Joshi U, Kilani B, Hoseinpour P, Thakur M, Grünauer P, Pfeiler S, Schmidergall T, Stockhausen S, Bäumer M, Chandraratne S, von Brühl ML, Lorenz M, Coletti R, Reese S, Laitinen I, Wörmann SM, Algül H, Bruns CJ, Ware J, Mackman N, Engelmann B, Massberg S. (2018)
    Distinct Pathogenesis of Pancreatic Cancer Microvesicle-Associated Venous Thrombosis Identifies New Antithrombotic Targets In Vivo.
    Arterioscler Thromb Vasc Biol. 38(4):772-786 [Project B02]
  • Souza-Almeida G, D'Avila H, Almeida PE, Luna-Gomes T, Liechocki S, Walzog B, Hepper I, Castro-Faria-Neto HC, Bozza PT, Bandeira-Melo C, Maya-Monteiro CM. (2018)
    Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1.
    Front Immunol. 9:111 [Project A02]
  • Praetner M, Zuchtriegel G, Holzer M, Uhl B, Schaubächer J, Mittmann L, Fabritius M, Fürst R, Zahler S, Funken D, Lerchenberger M, Khandoga A, Kanse S, Lauber K, Krombach F, Reichel CA. (2018)
    Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion.
    Arterioscler Thromb Vasc Biol. 38(4):829-842 [Projects B03 and B06E]
  • Stremmel C, Schuchert R, Wagner F, Thaler R, Weinberger T, Pick R, Mass E, Ishikawa-Ankerhold HC, Margraf A, Hutter S, Vagnozzi R, Klapproth S, Frampton J, Yona S, Scheiermann C, Molkentin JD, Jeschke U, Moser M, Sperandio M, Massberg S, Geissmann F, Schulz C (2018)
    Yolk sac macrophage progenitors traffic to the embryo during defined stages of development.
    Nat Commun. 9(1):75 [Projects A10, Z03, A01, B01, B02 and Z01]
  • Novotny J, Chandraratne S, Weinberger T, Philippi V, Stark K, Ehrlich A, Pircher J, Konrad I, Oberdieck P, Titova A, Hoti Q, Schubert I, Legate KR, Urtz N, Lorenz M, Pelisek J, Massberg S, von Brühl ML, Schulz C. (2018)
    Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.
    PLoS One. 13(1):e0190728 [Projects A10 and B02]
  • Lautz T, Lasch M, Borgolte J, Troidl K, Pagel J-I, Caballero-Martinez A, Kleinert EC, Walzog B, Deindl E (2018)
    Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3
    EBioMedicine. 27:237-246 [Project A02]

2017

  • Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD (2017)
    Recurrent infection progressively disables host protection against intestinal inflammation.
    Science. 358(6370) [Project B01]
  • Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S. (2017)
    Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.
    Cell. 171(6):1368-1382.e23 [Projects Z01, B02, A05, B04E, B05 and B06E)
  • Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R. (2017)
    Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.
    J Cell Biol. 216(11):3785-3798 [Project A05]
  • Prüss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, Mazo IB, Kopp MA, Brommer B, Blex C, Geurtz LC, Liebscher T, Niedeggen A, Dirnagl U, Bradke F, Volz MS, DeVivo MJ, Chen Y, von Andrian UH, Schwab JM. (2017)
    Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.
    Nat Neurosci. 20(11):1549-1559 [Project A06]
  • Begandt D, Thome S, Sperandio M, Walzog B. (2017)
    How neutrophils resist shear stress at blood vessel walls: molecular mechanisms, subcellular structures, and cell-cell interactions.
    J Leukoc Biol. 102(3):699-709 [Review, Projects A02, B01 and Z03]
  • Pick R, Begandt D, Stocker TJ, Salvermoser M, Thome S, Böttcher RT, Montanez E, Harrison U, Forné I, Khandoga AG, Coletti R, Weckbach LT, Brechtefeld D, Haas R, Imhof A, Massberg S, Sperandio M, Walzog B. (2017)
    Coronin 1A – a novel player in integrin biology – controls neutrophil trafficking in innate immunity.
    Blood. 130(7):847-858 [Projects A02, A05, B01, B02, B05, Z01 and Z03]
  • Funken D, Ishikawa-Ankerhold H, Uhl B, Lerchenberger M, Rentsch M, Mayr D, Massberg S, Werner J, Khandoga A. (2017)
    In situ targeting of dendritic cells sets tolerogenic environment and ameliorates CD4(+) T-cell response in the postischemic liver.
    FASEB J. 31(11):4796-4808 [Project Z01]
  • Roth H, Samereier M, Begandt D, Pick R, Salvermoser M, Brechtefeld D, Schleicher M, Walzog B, Müller-Taubenberger A. (2017)
    Filamin A promotes efficient migration and phagocytosis of neutrophil-like HL-60 cells.
    Eur J Cell Biol. 96(6):553-566 [Projects A07E, A02 and Z03]
  • Steffens S, Winter C, Schloss MJ, Hidalgo A, Weber C, Soehnlein O. (2017)
    Circadian Control of Inflammatory Processes in Atherosclerosis and Its Complications.
    Arterioscler Thromb Vasc Biol. 37(6):1022-1028 [Review, Project B08]
  • Margraf A, Nussbaum C, Rohwedder I, Klapproth S, Kurz ARM, Florian A, Wiebking V, Pircher J, Pruenster M, Immler R, Dietzel S, Kremer L, Kiefer F, Moser M, Flemmer AW, Quackenbush E, von Andrian UH, Sperandio M. (2017)
    Maturation of Platelet Function During Murine Fetal Development In Vivo.
    Arterioscler Thromb Vasc Biol. 37(6):1076-1086 [Projects B01 and A01]
  • Stocker TJ, Ishikawa-Ankerhold H, Massberg S, Schulz C. (2017)
    Small but mighty: Platelets as central effectors of host defense.
    Thromb Haemost. 2017 117(4):651-661 [Review, Project Z01]
  • Soehnlein O, Steffens S, Hidalgo A, Weber C. (2017)
    Neutrophils as protagonists and targets in chronic inflammation.
    Nat Rev Immunol. 2017 17(4):248-261 [Review, Project B08]
  • Blank B, von Blume J. (2017)
    Cab45-Unraveling key features of a novel secretory cargo sorter at the trans-Golgi network.
    Eur J Cell Biol. 96(5):383-390
    [Review, Project A09]
  • Samereier M, Schleicher M, Roth H, Brechtefeld D, Walzog B, Müller-Taubenberger A. (2017)
    EB1 contributes to proper front-to-back polarity in neutrophil-like HL-60 cells.
    Eur J Cell Biol. 96(2):143-153 [Projects A07(E) and A02]
  • Uhl B, Hirn S, Immler R, Mildner K, Möckl L, Sperandio M, Bräuchle C, Reichel CA, Zeuschner D, Krombach F. (2017)
    The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood-Tissue Border.
    ACS Nano. 11(2):1498-1508 [Project Z03]
  • de Jong RJ, Paulin N, Lemnitzer P, Viola JR, Winter C, Ferraro B, Grommes J, Weber C, Reutelingsperger C, Drechsler M, Soehnlein O. (2017)
    Protective Aptitude of Annexin A1 in Arterial Neointima Formation in Atherosclerosis-Prone Mice.
    Arterioscler Thromb Vasc Biol. 37(2):312-315 [Project B08]
  • Schober T, Magg T, Laschinger M, Rohlfs M, Linhares ND, Puchalka J, Weisser T, Fehlner K, Mautner J, Walz C, Hussein K, Jaeger G, Kammer B, Schmid I, Bahia M, Pena SD, Behrends U, Belohradsky BH, Klein C, Hauck F. (2017)
    A human immunodeficiency syndrome caused by mutations in CARMIL2.
    Nat Commun. 8:14209 [Projects A04(E) and A08]
  • Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C. (2017)
    Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses.
    Immunity 46(1):120-132 [Projects B09, Z03 and B05]
  • Benito-Jardón M, Klapproth S, Gimeno-LLuch I, Petzold T, Bharadwaj M, Müller DJ, Zuchtriegel G, Reichel CA, Costell M. (2017)
    The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes.
    eLife 6:e22264 [Project B03]
  • Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I. (2017)
    AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis.
    Circ Res. 120(1):99-109 [Project A02]

2016

  • Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E. (2016)
    Rac signal adaptation controls neutrophil mobilization from the bone marrow.
    Sci Signal. 9(459):ra124 [Project Z03]
  • Jörger AK, Liu L, Fehlner K, Weisser T, Cheng Z, Lu M, Höchst B, Bolzer A, Wang B, Hartmann D, Assfalg V, Sunami Y, Schlitter AM, Friess H, Hüser N, Laschinger M. (2016)
    Impact of NKT Cells and LFA-1 on Liver Regeneration under Subseptic Conditions.
    PLoS One. 11(12):e0168001 [Project A04(E)]
  • Gaertner F, Massberg S. (2016)
    Blood coagulation in immunothrombosis – At the frontline of intravascular immunity.
    Semin Immunol. 28(6):561-569 [Review, Project B02]
  • Petzold T, Thienel M, Konrad I, Schubert I, Regenauer R, Hoppe B, Lorenz M, Eckart A, Chandraratne S, Lennerz C, Kolb C, Braun D, Jamasbi J, Brandl R, Braun S, Siess W, Schulz C, Massberg S. (2016)
    Oral thrombin inhibitor aggravates platelet adhesion and aggregation during arterial thrombosis.
    Sci Transl Med. 8(367):367ra168 [Projects B02 and A10]
  • Mana G, Clapero F, Panieri E, Panero V, Böttcher RT, Tseng HY, Saltarin F, Astanina E, Wolanska KI, Morgan MR, Humphries MJ, Santoro MM, Serini G, Valdembri D. (2016)
    PPFIA1 drives active a5ß1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.
    Nat Commun. 7:13546 [Project A05]
  • Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gärtner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S. (2016)
    Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.
    Blood. 128(20):2435-2449 [Projects B02 and B01]
  • Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M. (2016)
    MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.
    J Clin Invest. 126(11):4125-4139 [Projects B01, A02, A01, A08 and B05]
  • Ortega Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong R, Megens RT, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O. (2016)
    Cathepsin G Controls Arterial But Not Venular Myeloid Cell Recruitment.
    Circulation 134(16):1176-1188 [Projects B08, A02, B09 and Z03]
  • Königer V, Holsten L, Harrison U, Busch B, Loell E, Zhao Q, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg EJ, Zimmermann W, Fischer W, Hauck CR, Haas R. (2016)
    Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.
    Nat Microbiol. 2:16188 [Project B05]
  • Csépányi-Kömi R, Wisniewski É, Bartos B, Lévai P, Németh T, Balázs B, Kurz AR, Bierschenk S, Sperandio M, Ligeti E. (2016)
    Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice.
    J Immunol. 197(7):2807-15 [Project B01]
  • Daniel JM, Reichel CA, Schmidt-Woell T, Dutzmann J, Zuchtriegel G, Krombach F, Herold J, Bauersachs J, Sedding DG, Kanse SM. (2016)
    Factor VII activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation.
    J Thromb Haemost. 14(10):2058-2067 [Project B03]
  • Lange M, Prassler J, Ecke M, Müller-Taubenberger A, Gerisch G. (2016)
    Local Ras activation, PTEN pattern, and global actin flow in the chemotactic responses of over-sized cells.
    J Cell Sci. 129(18):3462-72 [Project A07(E)]
  • Uhl B, Vadlau Y, Zuchtriegel G, Nekolla K, Sharaf K, Gaertner F, Massberg S, Krombach F, Reichel CA. (2016)
    Aged neutrophils contribute to the first line of defense in the acute inflammatory response.
    Blood 128(19):2327-37 [Projects B03 and B02]
  • Sun Z, Tseng HY, Tan S, Senger F, Kurzawa L, Dedden D, Mizuno N, Wasik AA, Thery M, Dunn AR, Fässler R. (2016)
    Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.
    Nat Cell Biol. 18(9):941-53 [Project A05]
  • Chillo O, Kleinert EC, Lautz T, Lasch M, Pagel JI, Heun Y, Troidl K, Fischer S, Caballero-Martinez A, Mauer A, Kurz AR, Assmann G, Rehberg M, Kanse SM, Nieswandt B, Walzog B, Reichel CA, Mannell H, Preissner KT, Deindl E. (2016)
    Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function.
    Cell Rep. 16(8):2197-207 [Projects A02 and B03]
  • Schloss MJ, Horckmans M, Nitz K, Duchene J, Drechsler M, Bidzhekov K, Scheiermann C, Weber C, Soehnlein O, Steffens S. (2016)
    The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment.
    EMBO Mol Med. 8(8):937-48 [Project B09]
  • Broadley SP, Plaumann A, Coletti R, Lehmann C, Wanisch A, Seidlmeier A, Esser K, Luo S, Rämer PC, Massberg S, Busch DH, van Lookeren Campagne M, Verschoor A. (2016)
    Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity.
    Cell Host Microbe. 20(1):36-48 [Projects B04(E) and Z01]
  • Kinzel L, Ernst A, Orth M, Albrecht V, Hennel R, Brix N, Frey B, Gaipl US, Zuchtriegel G, Reichel CA, Blutke A, Schilling D, Multhoff G, Li M, Niyazi M, Friedl AA, Winssinger N, Belka C, Lauber K. (2016)
    A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.
    Oncotarget. 7(28):43199-43219 [Projects B06(E) and B03]
  • Utsch C, Haas R. (2016)
    VacA's Induction of VacA-Containing Vacuoles (VCVs) and Their Immunomodulatory Activities on Human T Cells.
    Toxins. 8(6) pii: E190 [Review Project B05]
  • van Eeuwijk JM, Stegner D, Lamb DJ, Kraft P, Beck S, Thielmann I, Kiefer F, Walzog B, Stoll G, Nieswandt B. (2016)
    The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction.
    Arterioscler Thromb Vasc Biol. 36(6):1247-53 [Project A02]
  • Kumar Vr S, Darisipudi MN, Steiger S, Devarapu SK, Tato M, Kukarni OP, Mulay SR, Thomasova D, Popper B, Demleitner J, Zuchtriegel G, Reichel C, Cohen CD, Lindenmeyer MT, Liapis H, Moll S, Reid E, Stitt AW, Schott B, Gruner S, Haap W, Ebeling M, Hartmann G, Anders HJ. (2015)
    Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
    J Am Soc Nephrol. 27(6):1635-49 [Project B03]
  • Wichapong K, Alard JE, Ortega-Gomez A, Weber C, Hackeng TM, Soehnlein O, Nicolaes GA. (2016) Structure-Based Design of Peptidic Inhibitors of the Interaction between Chemokine 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1).
    J Med Chem. 59(9):4289-301 [Project B08]
  • Crevenna AH, Blank B, Maiser A, Emin D, Prescher J, Beck G, Kienzle C, Bartnik K, Habermann B, Pakdel M, Leonhardt H, Lamb DC, von Blume J. (2016)
    Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network.
    J Cell Biol. 213(3):305-14 [Project A09]
  • Silvestre-Roig C, Hidalgo A, Soehnlein O. (2016)
    Neutrophil heterogeneity: implications for homeostasis and pathogenesis.
    Blood. 127(18):2173-81 [Review Project B08]
  • Zuchtriegel G, Uhl B, Puhr-Westerheide D, Pörnbacher M, Lauber K, Krombach F, Reichel CA. (2016)
    Platelets Guide Leukocytes to Their Sites of Extravasation.
    PLoS Biol. 14(5):e1002459 [Projects B06 and B03]
  • Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Bräsen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ. (2016)
    Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.
    Nat Commun. 7:10274 [Project B03]
  • Vargas P, Maiuri P, Bretou M, Sáez PJ, Pierobon P, Maurin M, Chabaud M, Lankar D, Obino D, Terriac E, Raab M, Thiam HR, Brocker T, Kitchen-Goosen SM, Alberts AS, Sunareni P, Xia S, Li R, Voituriez R, Piel M, Lennon-Duménil AM. (2016)
    Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells.
    Nat Cell Biol. 18(1):43-53 [Project A06]

2015

  • Klapproth S, Moretti FA, Zeiler M, Ruppert R, Breithaupt U, Mueller S, Haas R, Mann M, Sperandio M, Fässler R, Moser M. (2015)
    Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice.
    Blood. 126(24):2592-600 [Projects A01, A05, B01 & B05]
  • Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D'Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O. (2015)
    Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5.
    Sci Transl Med. 7(317):317ra196 [Projects B08 & B09]
  • Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C, Hilbi H. (2015)
    Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway.
    PLoS Pathog. 11(12) [Project B07(E)]
  • Milde R, Ritter J, Tennent GA, Loesch A, Martinez FO, Gordon S, Pepys MB, Verschoor A, Helming L. (2015)
    Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction.
    Cell Rep. 13(9):1937-48 [Project B04]
  • Kern B, Jain U, Utsch C, Otto A, Busch B, Jiménez-Soto L, Becher D, Haas R. (2015)
    Characterization of Helicobacter pylori VacA-containing vacuoles (VCVs), VacA intracellular trafficking and interference with calcium signalling in T-lymphocytes.
    Cell Microbiol. 17(12):1811-32 [Project B05]
  • Lauber K, Brix N, Ernst A, Hennel R, Krombach J, Anders H, Belka C. (2015)
    Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity.
    Cancer Lett. 368(2):209-29 [Project B06]
  • Roth H, Samereier M, Trommler G, Noegel AA, Schleicher M, Müller-Taubenberger A. (2015)
    Balanced cortical stiffness is important for efficient migration of Dictyostelium cells in confined environments.
    Biochem Biophys Res Commun. 467(4):730-5. [Project A07]
  • Schulz AM, Stutte S, Hogl S, Luckashenak N, Dudziak D, Leroy C, Forné I, Imhof A, Müller SA, Brakebusch CH, Lichtenthaler SF, Brocker T. (2015)
    Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.
    J Cell Biol. 211(3):553-67 [Project A06]
  • Li S, Dislich B, Brakebusch CH, Lichtenthaler SF, Brocker T. (2015)
    Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.
    J Immunol. 195(9):4244-56 [Project A06]
  • Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu WH, Schulz AS, Oostendorp RA, Massberg S, Fässler R. (2015)
    Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.
    J Exp Med. 212(9):1415-32 [Projects A05, A01, B01 & Z01]
  • Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Döring Y, Herias V, Gijbels M, Bot I, de Jager SC, Weber C, Cleutjens J, van Berkel TJ, Sikkink KJ, Mócsai A, Maridonneau-Parini I, Soehnlein O, Biessen EA. (2015)
    Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility.
    Circulation. 132(6):490-501 [Project B08]
  • Mócsai A, Walzog B, Lowell CA. (2015)
    Intracellular signaling during neutrophil recruitment.
    Cardiovasc Res. 107(3):373-85 [Review, Project A02]
  • Heinig K, Sage F, Robin C, Sperandio M. (2015)
    Development and trafficking function of hematopoietic stem cells and myeloid cells during fetal ontogeny.
    Cardiovasc Res. 107(3):352-63 [Review, Project B01]
  • Pruenster M, Kurz ARM, Chung K-J, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leanderson T, Chavakis T, Roth J, Vogl T, Sperandio M. (2015)
    Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.
    Nat Commun. 6:6915 [Projects A01, B04 & B01]
  • Nussbaum C, Bannenberg S, Keul P, Gräler MH, Gonçalves-de-Albuquerque CF, Korhonen H, von Wnuck Lipinski K, Heusch G, de Castro Faria Neto HC, Rohwedder I, Göthert JR, Prasad VP, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M, Levkau B. (2015)
    Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.
    Nat Commun. 6:6416 [Project B01]
  • Drechsler M, Duchene J, Soehnlein O. (2015)
    Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis.
    Arterioscler Thromb Vasc Biol. 35(5):1050-5 [Review, Project B08]
  • Viola J, Soehnlein O. (2015)
    Atherosclerosis – A matter of unresolved inflammation.
    Semin Immunol. 27(3):184-93 [Review, Project B08]
  • Busch B, Weimer R, Woischke C, Fischer W, Haas R. (2015)
    Helicobacter pylori interferes with leukocyte migration via the outer membrane protein HopQ and via CagA translocation.
    Int J Med Microbiol. 305(3):355-64 [Project B05]
  • Zuchtriegel G, Uhl B, Hessenauer ME, Kurz AR, Rehberg M, Lauber K, Krombach F, Reichel CA. (2015)
    Spatiotemporal Expression Dynamics of Selectins Govern the Sequential Extravasation of Neutrophils and Monocytes in the Acute Inflammatory Response.
    Arterioscler Thromb Vasc Biol. 35(4):899-910 [Projects B03 & B06]
  • Lorenz V, Stegner D, Stritt S, Vögtle T, Kiefer F, Witke W, Schymeinsky J, Watson SP, Walzog B, Nieswandt B. (2015)
    Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.
    Blood. 125(26):4069-77 [Project A02]
  • Yazlovitskaya EM, Tseng HY, Viquez O, Tu T, Mernaugh G, McKee KK, Riggins K, Quaranta V, Pathak A, Carter BD, Yurchenco P, Sonnenberg A, Böttcher RT, Pozzi A, Zent R. (2015)
    Integrin a3ß1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.
    Mol Biol Cell. 26(10):1857-74 [Project A05]
  • Patzelt J, Verschoor A, Langer HF. (2015)
    Platelets and the complement cascade in atherosclerosis.
    Front Physiol. 6:49 [Review, Project B04]
  • Chandraratne S, von Bruehl ML, Pagel JI, Stark K, Kleinert E, Konrad I, Farschtschi S, Coletti R, Gärtner F, Chillo O, Legate KR, Lorenz M, Rutkowski S, Caballero-Martinez A, Starke R, Tirniceriu A, Pauleikhoff L, Fischer S, Assmann G, Mueller-Hoecker J, Ware J, Nieswandt B, Schaper W, Schulz C, Deindl E, Massberg S. (2015)
    Critical Role of Platelet Glycoprotein Ibα in Arterial Remodeling.
    Arterioscler Thromb Vasc Biol. 35(3):589-97 [Project B02]
  • Drechsler M, de Jong RJ, Rossaint J, Viola J, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Doering Y, Zarbock A, Soehnlein O. (2015)
    Annexin A1 Counteracts Chemokine-Induced Arterial Myeloid Cell Recruitment.
    Circ Res. 116(5):827-35 [Project B08]
  • Orban M, Goedel A, Haas J, Sandrock-Lang K, Gärtner F, Jung CB, Zieger B, Parrotta E, Kurnik K, Sinnecker D, Wanner G, Laugwitz KL, Massberg S, Moretti A. (2015)
    Functional Comparison of Induced Pluripotent Stem Cell- and Blood-Derived GPIIbIIIa Deficient Platelets.
    PLoS One. 10(1):e0115978 [Project B02]
  • Wunderlich R, Ernst A, Rödel F, Fietkau R, Ott O, Lauber K, Frey B, Gaipl US. (2015)
    Low and moderate dose of ionising radiation up to 2 Gy modulates transmigration and chemotaxis of activated macrophages, provokes an anti-inflammatory cytokine milieu, but does not impact on viability and phagocytic function.
    Clin Exp Immunol. 179(1):50-61 [Project B06]

2014

  • Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS. (2014)
    Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
    Nat Med. 20(11):1315-1320 [associated project *B09]
  • Tseng HY, Thorausch N, Ziegler T, Meves A, Fässler R, Böttcher RT. (2014)
    Sorting Nexin 31 Binds Multiple ß Integrin Cytoplasmic Domains and Regulates ß1 Integrin Surface Levels and Stability.
    J Mol Biol. 426(18):3180-94 [Project A05]
  • Zeiler M, Moser M, Mann M. (2014)
    Copy number analysis of the murine platelet proteome spanning the complete abundance range.
    Mol Cell Proteomics. 13(12):3435-45 [Project A01]
  • Boztug K, Järvinen PM, Salzer E, Racek T, Mönch S, Garncarz W, Gertz EM, Schäffer AA, Antonopoulos A, Haslam SM, Schieck L, Puchalka J, Diestelhorst J, Appaswamy G, Lescoeur B, Giambruno R, Bigenzahn JW, Elling U, Pfeifer D, Conde CD, Albert MH, Welte K, Brandes G, Sherkat R, van der Werff Ten Bosch J, Rezaei N, Etzioni A, Bellanné-Chantelot C, Superti-Furga G, Penninger JM, Bennett KL, von Blume J, Dell A, Donadieu J, Klein C. (2014)
    JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.
    Nat Genet. 46(9):1021-7 [Project A08]
  • Wirnsberger G, Zwolanek F, Stadlmann J, Tortola L, Liu SW, Perlot T, Järvinen P, Dürnberger G, Kozieradzki I, Sarao R, De Martino A, Boztug K, Mechtler K, Kuchler K, Klein C, Elling U, Penninger JM. (2014)
    Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.
    Nat Genet. 46(9):1028-33 [Project A08]
  • Wan M, Soehnlein O, Tang X, van der Does AM, Smedler E, Uhlén P, Lindbom L, Agerberth B, Haeggström JZ. (2014)
    Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo.
    FASEB J. 28(8):3456-67 [Project B08]
  • Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I. (2014)
    Rubbing salt into wounded endothelium: Sodium potentiates proatherogenic effects of TNF-α under non-uniform shear stress.
    Thromb Haemost. 112(1):183-95 [Project B08]
  • Müller-Taubenberger A, Kastner PM, Schleicher M, Bolourani P, Weeks G. (2014)
    Regulation of a LATS-homolog by Ras GTPases is important for the control of cell division.
    BMC Cell Biol. 15:25 [Project A07]
  • Uhl B, Zuchtriegel G, Puhr-Westerheide D, Praetner M, Rehberg M, Fabritius M, Hessenauer M, Holzer M, Khandoga A, Fürst R, Zahler S, Krombach F, Reichel CA. (2014)
    Tissue-Type Plasminogen Activator Promotes Postischemic Neutrophil Recruitment via Its Proteolytic and Nonproteolytic Properties.
    Arterioscler Thromb Vasc Biol. 34(7):1495-504 [Project B03]
  • Simon S, Wagner MA, Rothmeier E, Müller-Taubenberger A, Hilbi H. (2014)
    Icm/Dot-dependent inhibition of phagocyte migration by Legionella is antagonized by a translocated Ran GTPase activator.
    Cell. Microbiol. 16(7):977-92 [Projects B07 & A07]
  • Gaipl US, Multhoff G, Scheithauer H, Lauber K, Hehlgans S, Frey B, Rödel F. (2014)
    Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy.
    Immunotherapy. 6(5):597-610 [Review, Project B06]
  • Schiener M, Hossann M, Viola JR, Ortega-Gomez A, Weber C, Lauber K, Lindner LH, Soehnlein O. (2014)
    Nanomedicine-based strategies for treatment of atherosclerosis.
    Trends Mol Med. 20(5):271-281 [Review, Projects B08 & B06]
  • Rossaint J, Herter JM, Van Aken H, Döring Y, Weber C, Soehnlein O, Zarbock A. (2014)
    Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap mediated sterile inflammation.
    Blood. 123(16):2573-84 [Project B08]
  • Hennel R, Brix N, Seidl K, Ernst A, Scheithauer H, Belka C, Lauber K. (2014)
    Release of monocyte migration signals by breast cancer cell lines after ablative and fractionated gamma-irradiation.
    Radiation Oncol. 26;9(1):85 [Project B06]
  • Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, Müller-Höcker J, Deindl E, Sperandio M, Walzog B. (2014)
    The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ß2 integrins (CD11/CD18).
    Blood. 123(12):1887-96 [Projects A02 & B01]
  • Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte K, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E. (2014)
    Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
    Proc Natl Acad Sci USA. 111(7):2686-91 [Project B08]
  • Wildhagen KC, García de Frutos P, Reutelingsperger CP, Schrijver R, Aresté C, Ortega-Gómez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA. (2014)
    Non-anticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.
    Blood 123(7):1098-101 [Project B08]
  • Weber S, Wagner M, Hilbi H. (2014)
    Live-Cell Imaging of Phosphoinositide Dynamics and Membrane Architecture during Legionella Infection.
    MBio. 5(1):e00839-13 [Project B07]
  • Druzd D, de Juan A, Scheiermann C. (2014)
    Circadian rhythms in leukocyte trafficking.
    Semin Immunopathol. 36(2):149-62 [Review, associated Project *B09]
  • Döring Y, Noels H, Mandl MM, Kramp B, Neideck C, Lievens D, Drechsler M, Megens RT, Tilstam PV, Langer M, Hartwig H, Theelen W, Marth JD, Sperandio M, Soehnlein O, Weber C. (2014)
    Deficiency of the Sialyltransferase St3Gal4 Reduces Ccl5-Mediated Myeloid Cell Recruitment and Arrest.
    Circ Res. 114(6):976-81 [Projects B08 & B01]
  • Chèvre R, González-Granado JM, Megens RT, Sreeramkumar V, Silvestre-Roig C, Molina-Sanchez P, Weber C, Soehnlein O, Hidalgo A, Andrés V. (2014)
    High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice.
    Circ Res. 114(5):770-9 [Project B08]
  • Swaminathan K, Müller-Taubenberger A, Faix J, Rivero F, Noegel AA. (2014)
    A Cdc42- and Rac-interactive binding (CRIB) domain mediates functions of coronin.
    Proc Natl Acad Sci U S A. 111(1):E25-33 [Project A07]
  • Schmitt MM, Megens RT, Zernecke A, Bidzhekov K, van den Akker NM, Rademakers T, van Zandvoort MA, Hackeng TM, Koenen RR, Weber C. (2014)
    Endothelial JAM-A Guides Monocytes into Flow-Dependent Predilection Sites of Atherosclerosis.
    Circulation 129(1):66-76 [Project B08]
  • Glöckner G, Hülsmann N, Schleicher M, Noegel AA, Eichinger L, Gallinger C, Pawlowski J, Sierra R, Euteneuer U, Pillet L, Moustafa A, Platzer M, Groth M, Szafranski K, Schliwa M. (2014)
    The Genome of the Foraminiferan Reticulomyxa filosa.
    Curr Biol. 24(1):11-8 [Project A07]
  • Hilbi H, Rothmeier E, Hoffmann C, Harrison CF. (2014)
    Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.
    Small GTPases. 5(3):1-6 [Review, Project B07]
  • Grommes J, Drechsler M, Soehnlein O. (2014)
    CCR5 and FPR1 Mediate Neutrophil Recruitment in Endotoxin-Induced Lung Injury.
    J Innate Immun. 6:111-6 [Project B08]
  • Silvestre-Roig C, de Winther MP, Weber C, Daemen MJ, Lutgens E, Soehnlein O. (2014)
    Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies.
    Circ Res. 114(1):214-26
    [Review, Project B08]

2013

  • Meves A, Stremmel C, Böttcher RT, Fässler R. (2013)
    β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis.
    J Invest Dermatol. 133(12):2722-31 [Project A05]
  • Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A, Frenette PS. (2013)
    Arteriolar niches maintain haematopoietic stem cell quiescence.
    Nature 502(7473):637-43 [associated Project *B09]
  • Petzold T, Ruppert R, Pandey D, Barocke V, Meyer H, Lorenz M, Zhang L, Siess W, Massberg S, Moser M. (2013)
    β1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse.
    Blood 122(15):2723-2731 [Projects A01 & B02]
  • Moretti FA, Moser M, Lyck R, Abadier M, Ruppert R, Engelhardt B, Fässler R. (2013)
    Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.
    Proc Natl Acad Sci U S A. 110(42):17005-10 [Projects A01 & A05]
  • Leierseder S, Petzold T, Zhang L, Loyer X, Massberg S, Engelhardt S. (2013)
    MiR-223 is dispensable for platelet production and function in mice.
    Thromb Haemost. 110(6):1207-14 [Project B02]
  • Lauber K, Keppeler H, Munoz LE, Koppe U, Schröder K, Yamaguchi H, Krönke G, Uderhardt S, Wesselborg S, Belka C, Nagata S, Herrmann M. (2013)
    Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.
    Cell Death Differ. 20(9):1230-40 [Project B06]
  • Druzd D, Scheiermann C. (2013).
    Some Monocytes Got Rhythm.
    Science 341, 1462-64 [Perspective, associated Project *B09]
  • Rothmeier E, Pfaffinger G, Hoffmann C, Harrison CF, Grabmayr H, Repnik U, Hannemann M, Wölke S, Bausch A, Griffith G, Müller-Taubenberger A, Itzen A, Hilbi H. (2013)
    Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection.
    PLoS Pathog 9(9): e1003598 [Projects B07 & A07]
  • Müller R, Herr C, Sukumaran SK, Omosigho NN, Plomann M, Riyahi TY, Stumpf M, Swaminathan K, Tsangarides M, Yiannakou K, Blau-Wasser R, Gallinger C, Schleicher M, Kolanus W, Noegel AA. (2013)
    The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.
    Cell Commun Signal 1;11:54 [Project A07]
  • Verschoor A, Langer HF. (2013)
    Crosstalk between platelets and the complement system in immune protection and disease.
    Thromb Haemost. 110(5):910-9  [Review, Project B04]
  • Fischer W, Busch B. (2013)
    The Helicobacter pylori CagA protein: A multifunctional bacterial toxin delivered by type IV secretion.
    In: Bacterial Toxins: Genetics, Cellular Biology and Practical Applications; T. Proft, Ed., Caister Academic Press, Norfolk, UK; pp. 13-45 [Review, Project B05]
  • Finsel I, Ragaz C, Hoffmann C, Harrison CF, Weber S, van Rahden VA, Johannes L, Hilbi H. (2013)
    The Legionella Effector RidL Inhibits Retrograde Trafficking to Promote Intracellular Replication.
    Cell Host Microbe. 14(1):38-50 [Project B07]
  • Schulz C, Engelmann B, Massberg S. (2013)
    Crossroads of coagulation and innate immunity: the case of deep vein thrombosis.
    J Thromb Haemost. 11 (Suppl 1): 233-41 [Review, Projects B02 & Z01]
  • Harwood AJ, Forde-Thomas JE, Williams H, Samereier M, Müller-Taubenberger A. (2013)
    Aberrant spindle dynamics and cytokinesis in Dictyostelium discoideum cells that lack glycogen synthase kinase 3.
    Eur J Cell Biol. 92(6-7):222-8 [Project A07]
  • Zhang L, Lukowski R, Gaertner F, Lorenz M, Legate KR, Domes K, Angermeier E, Hofmann F, Massberg S. (2013)
    Thrombocytosis as a Response to High Interleukin-6 Levels in cGMP-Dependent Protein Kinase I Mutant Mice.
    Arterioscler Thromb Vasc Biol. 33(8):1820-1828 [Project B02]
  • Zhang L, Urtz N, Gaertner F, Legate KR, Petzold T, Lorenz M, Mazharian A, Watson SP, Massberg S. (2013)
    Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P).
    Blood 122(5):791-802 [Project B02]
  • Lerchenberger M, Uhl B, Stark K, Zuchtriegel G, Eckart A, Miller M, Puhr-Westerheide D, Praetner M, Rehberg M, Khandoga AG, Lauber K, Massberg S, Krombach F, Reichel CA. (2013)
    Matrix metalloproteinases modulate ameboid-like migrationof neutrophils through inflamed interstitial tissue.
    Blood 122(5):770-80 [Projects B03, B06 & Z01]
  • Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. (2013)
    Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance.
    Cell 153(5):1025-1035 [Project B08]
  • Buchholz VR, Flossdorf M, Hensel I, Kretschmer L, Weissbrich B, Gräf P, Verschoor A, Schiemann M, Höfer T, Busch DH. (2013)
    Disparate individual fates compose robust CD8+ T cell immunity.
    Science 340(6132):630-5 [Project B04]
  • Ortega-Gómez A, Perretti M, Soehnlein O. (2013)
    Resolution of inflammation: an integrated view.
    EMBO Mol Med. 5(5):661-74 [Review, Project B08]
  • Drechsler M, Soehnlein O. (2013)
    The complexity of arterial classical monocyterecruitment.
    J Innate Immun. 5(4):358-66 [Review, Project B08]
  • *Lucas D, Scheiermann C, Chow A, Kunisaki Y, Bruns I, Barrick C, Tessarollo L, Frenette PS. (2013)
    Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.
    Nat Med. 19(6):695-703 [associated Project *B09]
  • Sperandio M, Quackenbush EJ, Sushkova N, Altstätter J, Nussbaum C, Schmid S, Pruenster M, Kurz A, Margraf A, Steppner A, Schweiger N, Borsig L, Boros I, Krajewski N, Genzel-Boroviczeny O, Jeschke U, Frommhold D, von Andrian UH. (2013)
    Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels.
    Blood 121(21):e118-28 [Project B01]
  • Jakob SM, Pick R, Brechtefeld D, Nussbaum C, Kiefer F, Sperandio M, Walzog B. (2013)
    Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response.
    Blood 121(20):4184-94 [Projects A02 & B01]
  • Soehnlein O, Drechsler M, Döring Y, Lievens D, Hartwig H, Kemmerich K, Ortega-Gómez A, Mandl M, Vijayan S, Projahn D, Garlichs CD, Koenen RR, Hristov M, Lutgens E, Zernecke A, Weber C. (2013)
    Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes.
    EMBO Mol Med. 5(3):471-81 [Project B08]
  • * Scheiermann C, Kunisaki Y, Frenette PS. (2013)
    Circadian control of the immune system.
    Nat Rev Immunol. 13:190-198 [Review, associated Project *B09]
  • Soehnlein O, Swirski FK. (2013)
    Hypercholesterolemia links hematopoiesis with atherosclerosis.
    Trends Endocrinol Metab. 24(3):129-136 [Review, Project B08]
  • Müller-Taubenberger A, Kortholt A, Eichinger L. (2013)
    Simple system - substantial share: The use of Dictyostelium in cell biology and molecular medicine.
    Eur J Cell Biol. 92(2):45-53 [Review, Project A07]
  • Kellersch B, Brocker T. (2013)
    Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function.
    Blood 121(2):298-307 [Project A06]
  • Lenglet S, Thomas A, Soehnlein O, Montecucco F, Burger F, Pelli G, Galan K, Cravatt B, Staub C, Steffens S. (2013)
    Fatty Acid Amide Hydrolase Deficiency Enhances Intraplaque Neutrophil Recruitment in Atherosclerotic Mice.
    Arterioscler Thromb Vasc Biol. 33:215-223 [Project B08]
  • Nussbaum C, Gloning A, Pruenster M, Frommhold D, Bierschenk S, Genzel-Boroviczény O, von Andrian UH, Quackenbush E, Sperandio M. (2013)
    Neutrophil and endothelial adhesive function during human fetal ontogeny.
    J Leukoc Biol. 93:175-184 [Project B01]
  • Peche VS, Holak TA, Burgute BD, Kosmas K, Kale SP, Wunderlich FT, Elhamine F, Stehle R, Pfitzer G, Nohroudi K, Addicks K, Stöckigt F, Schrickel JW, Gallinger J, Schleicher M, Noegel AA. (2013)
    Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy.
    Cell Mol Life Sci. 70(3):527-43 [Project A07]
  • Schmidt S, Moser M, Sperandio M. (2013)
    The molecular basis of leukocyte recruitment and its deficiencies.
    Mol Immunol. 55(1):49-58 [Review, Projects B01 & A01]
  • Pick R, Brechtefeld D, Walzog B. (2013)
    Intraluminal crawling versus interstitial neutrophil migration during inflammation.
    Mol Immunol. 55(1):70-5 [Review, Project A02]
  • Wantha S, Alard JE, Megens RT, van der Does AM, Döring Y, Drechsler M, Pham CT, Wang MW, Wang JM, Gallo R, von Hundelshausen P, Lindbom L, Hackeng TM, Weber C, Soehnlein O. (2013)
    Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes.
    Circ Res. 112(5):792-801 [Project B08]
  • Stark K, Eckart A, Haidari S, Tirniceriu A, Lorenz M, von Brühl ML, Gärtner F, Khandoga AG, Legate KR, Pless R, Hepper I, Lauber K, Walzog B, Massberg S. (2013)
    Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs.
    Nat Immunol. 14, 41–51 [Projects Z01, A03, B02, B06 & A02]
  • Engelmann B, Massberg S. (2013)
    Thrombosis as an intravascular effector of innate immunity.
    Nat Rev Immunol. 13(1):34-45 [Review, Project B02]
  • Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T. (2013)
    Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
    J Immunol. 190(1):27-35 [Project A06]

2012

  • Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K. (2012)
    Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
    Autoimmunity. 45(8):568-73 [Project B06]
  • Harre U, Keppeler H, Ipseiz N, Derer A, Poller K, Aigner M, Schett G, Herrmann M, Lauber K. (2012)
    Moonlighting osteoclasts as undertakers of apoptotic cells.
    Autoimmunity. 45(8):612-9 [Project B06]
  • Rosenwald M, Koppe U, Keppeler H, Sauer G, Hennel R, Ernst A, Blume KE, Peter C, Herrmann M, Belka C, Schulze-Osthoff K, Wesselborg S, Lauber K. (2012)
    Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.
    J Immunol. 189(12):5722-5728. [Project B06]
  • Ittner A, Block H, Reichel CA, Varjosalo M, Gehart H, Sumara G, Gstaiger M, Krombach F, Zarbock A, Ricci R. (2012)
    Regulation of PTEN activity by p38δ-PKD1signaling in neutrophils confers inflammatory responses in the lung.
    J Exp Med. 209(12):2229-46 [Project B03]
  • Zhang L, Orban M, Lorenz M, Barocke V, Braun D, Urtz N, Schulz C, von Brühl ML, Tirniceriu A, Gaertner F, Proia RL, Graf T, Bolz SS, Montanez E, Prinz M, Müller A, von Baumgarten L, Billich A, Sixt M, Fässler R, von Andrian UH, Junt T, Massberg S. (2012)
    A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis.
    J Exp Med. 209(12):2165-81 [Projects B02 & A05]
  • Fischer S, Grantzow T, Pagel JI, Tschernatsch M, Sperandio M, Preissner KT, Deindl E. (2012)
    Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines.
    Thromb Haemost. 108(4):730-41 [Project B01]
  • Lauber K, Ernst A, Orth M, Herrmann M, Belka C. (2012)
    Dying cell clearance and its impact on the outcome of tumor radiotherapy.
    Front Oncol. 2:116 [Review, Project B06]
  • Reichel CA, Kanse SM, Krombach F. (2012)
    At the Interface of Fibrinolysis and Inflammation: The Role of Urokinase-Type Plasminogen Activator in the Leukocyte Extravasation Cascade.
    Trends Cardiovasc Med. 22(7):192-6 [Review, Project B03]
  • Cardilo-Reis L, Gruber S, Schreier SM, Drechsler M, Papac-Milicevic N, Weber C, Wagner O, Stangl H, Soehnlein O, Binder CJ. (2012)
    Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype.
    EMBO Mol Med. 4(10):1072-1086 [Project B08]
  • Gerisch G, Schroth-Diez B, Müller-Taubenberger A, Ecke M.(2012)
    PIP3 Waves and PTEN Dynamics in the Emergence of Cell Polarity.
    Biophys J. 103(6):1170-8 [Project A07]
  • Kaplan-Türköz B, Jiménez-Soto LF, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R, Terradot L (2012)
    Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin.
    Proc Natl Acad Sci USA. 109(36):14640-14645 [Project B05]
  • Weckbach LT, Groesser L, Borgolte J, Pagel JI, Pogoda F, Schymeinsky J, Müller-Höcker J, Shakibaei M, Muramatsu T, Deindl E, Walzog B. (2012)
    Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis.
    Am J Physiol Heart Circ Physiol. 303(4):H429-38 [Project A02]
  • Hilbi H, Haas A (2012)
    Secretive bacterial pathogens and the secretory pathway.
    Traffic 13(9):1187-97 [Review, Project B07]
  • Artemenko Y, Batsios P, Borleis J, Gagnon Z, Lee J, Rohlfs M, Sanséau D, Willard SS, Schleicher M, Devreotes PN (2012)
    Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion.
    Proc Natl Acad Sci USA. 109(34):13632-13637 [Project A07]
  • Yang WH, Nussbaum C, Grewal PK, Marth JD, Sperandio M (2012)
    Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands.
    Blood 120(5):1015-1026 [Project B01]
  • Reichel CA, Puhr-Westerheide D, Zuchtriegel G, Uhl B, Berberich N, Zahler S, Wymann MP, Luckow B, Krombach F (2012)
    C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms.
    Blood 120(4):880-90 [Project B03]
  • Allam R, Scherbaum CR, Darisipudi MN, Mulay SR, Hägele H, Lichtnekert J, Hagemann JH, Rupanagudi KV, Ryu M, Schwarzenberger C, Hohenstein B, Hugo C, Uhl B, Reichel CA, Krombach F, Monestier M, Liapis H, Moreth K, Schaefer L, Anders HJ (2012)
    Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4.
    J Am Soc Nephrol. 23(8):1375-88 [Project B03]
  • Böttcher, R.T., Stremmel, C., Meves, A., Meyer, H., Widmaier, M., Tseng, H.-Y., Fässler, R. (2012)
    Sorting nexin 17 prevents lysosomal degradation of ß1 integrins by binding to the ß1-integrin tail.
    Nature Cell Biology 14:584–592 [Project A05]
  • Lefort, C.T., Rossaint, J., Moser, M., Petrich, B.G., Zarbock, A., Monkley, S.J., Critchley, D.R., Ginsberg, M.H., Fässler, R., Ley, K. (2012)
    Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation.
    Blood 119(18):4275-82 [Projects A01 and A05]
  • Rohwedder, I., Montanez, E., Beckmann, K., Bengtsson, E., Dunér, P., Nilsson, J., Soehnlein, O., Fässler, R. (2012)
    Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation.
    EMBO Mol Med. 4:564–576 [Projects B08 and A05]
  • Hepper, I., Schymeinsky, J., Weckbach, L.T., Jakob, S.M., Frommhold, D., Sixt, M., Laschinger, M., Sperandio, M., Walzog, B. (2012)
    The Mammalian Actin-Binding Protein 1 Is Critical for Spreading and Intraluminal Crawling of Neutrophils under Flow Conditions.
    J Immunol. 188(9):4590-601 [Projects A02, A04 and B01]
  • von Brühl, M.L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A., Tirniceriu, A., Coletti, R., Köllnberger, M., Byrne, R.A., Laitinen, I., Walch, A., Brill, A., Pfeiler, S., Manukyan, D., Braun, S., Lange, P., Riegger, J., Ware, J., Eckart, A., Haidari, S., Rudelius, M., Schulz, C., Echtler, K., Brinkmann, V., Schwaiger, M., Preissner, K.T., Wagner, D.D., Mackman, N., Engelmann, B., Massberg, S. (2012)
    Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
    J Exp Med. 209(4):819-35 [Projects B02 and Z01]
  • Abdollahpour H, Appaswamy G, Kotlarz D, Diestelhorst J, Beier R, Schäffer AA, Gertz EM, Schambach A, Kreipe HH, Pfeifer D, Engelhardt KR, Rezaei N, Grimbacher B, Lohrmann S, Sherkat R, *Klein C. (2012)
    The phenotype of human STK4 deficiency.
    Blood 119(15):3450-7 [*SFB 900]
  • Soehnlein, O. (2012)
    Multiple roles for neutrophils in atherosclerosis.
    Circ Res 110(6):875-88 [Review, Project B08]
  • Futosi, K., Németh, T., Pick, R., Vántus, T., Walzog, B., Mócsai, A. (2012)
    Dasatinib inhibits pro-inflammatory functions of mature human neutrophils.
    Blood. 119(21):4981-91 [Project A02]
  • Döring, Y., Drechsler, M., Wantha, S., Kemmerich, K., Lievens, D., Vijayan, S., Gallo, R. L., Weber, C., Soehnlein, O. (2012)
    Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice.
    Circ Res. 110(8):1052-6 [Project B08]
  • Blume, K. E., Soeroes, S., Keppeler, H., Stevanovic, S., Kretschmer, D., Rautenberg, M., Wesselborg, S., Lauber, K. (2012)
    Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal.
    J Immunol. 188(1):135-45 [Project B06]

top

2011

  • Reichel, C. A., Uhl, B., Lerchenberger, M., Puhr-Westerheide, D., Rehberg, M., Liebl, J., Khandoga, A., Schmalix, W., Zahler, S., Deindl, E., Lorenzl, S., Declerck, P. J., Kanse, S., Krombach, F. (2011)
    Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptor.
    Circulation 124(17):1848-59 [Project B03]
  • Verschoor, A., Neuenhahn, M., Navarini, A. A., Graef, P., Plaumann, A., Seidlmeier, A., Nieswandt, B., Massberg, S., Zinkernagel, R. M., Hengartner, H., Busch, D. H. (2011)
    A platelet-mediated system for shuttling blood-borne bacteria to CD8a+ dendritic cells depends on glycoprotein GPIb and complement C3.
    Nat Immunol. 12(12): 1194-201 [Projects B04 and B02]