SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Emmy Noether junior research group joins SFB 914

Christoph Scheiermann to investigate circadian rhythms in the immune response


Christoph Scheiermann has been awarded the prestigious Emmy-Noether-Grant from the Deutsche Forschungs­gemeinschaft to head a research group focusing on circadian rhythms in the immune response. His group will be located at the Walter-Brendel-Centre of Experimental Medicine and will be associated with the SFB 914 "Trafficking of Immune Cells in Inflammation, Development and Disease".

Circadian oscillations in the recruitment of leukocytes

The recruitment of leukocytes to tissues and their localization within tissues plays a crucial role in the immune response. During his postdoc in the lab of Paul Frenette at the Mount Sinai School of Medicine and the Albert Einstein College of Medicine, New York, USA, Christoph Scheiermann showed that the recruitment of leukocytes to tissues underlies a circadian, i.e. daily rhythm (Scheiermann et al., Immunity 2012). This supports accumulating evidence for circadian oscillations in many components of the immune system with the potential to affect disease onset and therapies (Scheiermann et al., Nature Reviews Immunology 2013).

Novel insight into the systemic regulation of leukocyte trafficking

The group will study leukocyte migration patterns using various intravital microscopy techniques in different tissues. Specifically, the focus will be on how neural influences regulate the circadian migration of leukocytes to tissues, which promigratory factors control these rhythms and whether they can be altered by surgical, pharmacological or genetic interventions. The anticipated results will therefore provide new insight into our understanding of leukocyte trafficking with the potential to develop new therapies for inflammatory diseases using time-sensitive interventions.

Interested candidates for a postdoctoral or technical assistant position should contact Christoph Scheiermann directly.

Christoph Scheiermann, PhD
Walter-Brendel-Center of Experimental Medicine
Marchioninistr. 15
81377 München
Email: christoph.scheiermann@med.uni-muenchen.de