SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Junior Scientists of SFB 914 successful at ESM/EVBO meeting

Claudia Nussbaum receives Servier Award, Melanie Salvermoser wins poster award


Barbara Walzog and Markus Sperandio, both PIs of SFB 914, organized the symposium "Leukocyte trafficking in development and inflammation" at the joint meeting of the European Society of Microcirculation (ESM) and the European Vascular Biology Organisation (EVBO). The meeting took place in Pisa, June 3-6, 2015.

Melanie Salvermoser wins Poster Award

esm-evbo-poster-award-salvermoserMelanie Salvermoser, PhD student in Barbara Walzog’s lab (project A02), stood out among the almost 100 young scientists presenting their research in the poster session and was awarded the EVBO Young Investigators Award for the best poster.

Claudia Nussbaum receives Servier Award in Microcirculation

Nussbaum-Claudia-klDr. Claudia Nussbaum, former postdoc in Markus Sperandio’s lab (project B01) at the Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-Universität Munich, and Sarah Bannenberg (Institute of Pathophysiology, Universität Duisburg-Essen) received this year’s Servier Award in Microcirculation for their article: “Sphingosine-1-Phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin” published in Nature Communications in April 2015.

The prize is awarded every 2 years by the European Society for Microcirculation and sponsored by Servier for an outstanding publication in the field of microcirculation and vascular biology.

In the collaborative study, Claudia together with Bodo Levkau’s group at the Universität Duisburg-Essen investigated the role of sphingosine-1-phosphate and its receptor S1P3 in P-selectin-dependent leukocyte rolling. Leukocyte rolling is mediated by selectins and their ligands and an essential step during the recruitment of leukocytes from the intravascular compartment into inflamed tissue. Using intravital microscopy and a novel in vitro cell-based assay, Claudia could show that sphingosine-1-phosphate and its receptor S1P3 act as crucial regulators for P-selectin mobilization to the surface of endothelial cells which then is available to interact with selectin ligands on the leukocyte surface resulting in leukocyte rolling on inflamed endothelial cells.

Dr. Claudia Nussbaum currently works at the Dr. von Haunersches Kinderspital (director Prof. Dr. Christoph Klein, project A08) and will continue her studies on leukocyte recruitment by intravital imaging in collaboration with the Sperandio lab.

Nussbaum C*, Bannenberg S*, Keul P, Gräler M , Gonçalves-de-Albuquerque C, Korhonen H, von Wnuck Lipinski K, Heusch G, Caire de Castro-Faria-Neto H, Rohwedder I, Göthert J, Pushpa Prasad V, Haufe G, Lange-Sperandio B, Offermanns S, Sperandio M*, Levkau B* (2015) Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.
Nature Commun. 6:6416 (*shared authorship)

Dr. Claudia Nußbaum
Fachärztin für Kinder- und Jugendheilkunde
Dr. von Haunersches Kinderspital
Lindwurmstraße 4
80337 München
Tel: +49 89 4400 52811
Mail: claudia.nussbaum@med.uni-muenchen.de