SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Prof. Dr. rer. nat. Thomas Brocker


Project A06(E)


Institut für Immunologie

Biomedizinisches Centrum (BMC)
LMU München
Grosshadener Strasse 9
82152 Planegg-Martinsried

Phone: +49 89 2180-75674
Fax: +49 89 2180-9975674

10 most relevant publications:

1. Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T. (2013) Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol. 190(1):27-35.

2. Kellersch B, Brocker T. (2013) Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function. Blood. 121(2):298-307.

3. Edelmann SL, Nelson PJ, Brocker T. (2011) Comparative promoter analysis in vivo: identification of a dendritic cell-specific promoter module. Blood. 118(11):e40-9.

4. Ohnmacht C, Pullner A, King SB, Drexler I, Meier S, Brocker T, Voehringer D. (2009) Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med. 206(3):549-59.

5. Luckashenak N, Schroeder S, Endt K, Schmidt D, Mahnke K, Bachmann MF, Marconi P, Deeg CA, Brocker T. (2008) Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity. 28(4):521-32.

6. Neuenhahn M, Kerksiek KM, Nauerth M, Suhre MH, Schiemann M, Gebhardt FE, Stemberger C, Panthel K, Schröder S, Chakraborty T, Jung S, Hochrein H, Rüssmann H, Brocker T, Busch DH. (2006) CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity. 25(4):619-30.

7. Kerksiek KM, Niedergang F, Chavrier P, Busch DH, Brocker T. (2005) Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood. 105(2):742-9.

8. Kleindienst P, Chretien I, Winkler T, Brocker T. (2000) Functional comparison of thymic B cells and dendritic cells in vivo. Blood. 95(8):2610-6.

9. Brocker T, Riedinger M, Karjalainen K. (1997) Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med. 185(3):541-50.

10. Brocker T. (1997) Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J Exp Med. 186(8):1223-32.