Responsibilities
Project A05
Contact
Am Klopferspitz 18
82152 Martinsried
Phone:
+49 89 8578-2072
Fax:
+49 89 8578-2424
Email:
Faessler@biochem.mpg.de
10 most relevant publications:
1. Rognoni E, Widmaier M, Jakobson M, Ruppert R, Ussar S, Katsougkri D, Böttcher RT, Lai-Cheong JE, Rifkin DB, McGrath JA, Fässler R. (2014) Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation. Nat Med. 20(4):350-9.
2. Schiller HB, Hermann MR, Polleux J, Vignaud T, Zanivan S, Friedel CC, Sun Z, Raducanu A, Gottschalk KE, Thery M, Mann M, Fässler R. (2013) β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments. Nat Cell Biol. 15(6):625-36.
3. Schiller HB, Fässler R. (2013) Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep. 14(6):509-19 (Review).
4. Moretti FA, Moser M, Lyck R, Abadier M, Ruppert R, Engelhardt B, Fässler R. (2013) Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells. Proc Natl Acad Sci U S A. 110(42):17005-10.
5. Rohwedder I, Montanez E, Beckmann K, Bengtsson E, Duner P, Nilsson J, Soehnlein O, Fässler R. (2012) Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med. 4(7):564-76.
6. Böttcher RT, Stremmel C, Meves A, Meyer H, Widmaier M, Tseng HY, Fässler R. (2012) Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail. Nat Cell Biol. 14(6):584-92.
7. Schiller HB, Friedel CC, Boulegue C, Fässler R. (2011) Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep. 12(3):259-66.
8. Legate KR, Takahashi S, Bonakdar N, Fabry B, Boettiger D, Zent R, Fässler R. (2011) Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis. EMBO J. 30(22):4539-53.
9. Wickström SA, Lange A, Hess MW, Polleux J, Spatz JP, Krüger M, Pfaller K, Lambacher A, Bloch W, Mann M, Huber LA, Fässler R. (2010) Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell. 19(4):574-88.
10. Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R. (2009) Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature. 461(7266):1002-6.