Responsibilities
Project A04 (E)
Contact
Chirurgische Klinik und Poliklinik
Klinikum rechts der Isar
TU München
Ismaninger Str. 22
81675 München
Klinikum rechts der Isar
TU München
Ismaninger Str. 22
81675 München
Phone:
+49 89 4140-6604
Fax:
+49 89 4140-6605
Email:
melanie.laschinger@tum.de
Five most relevant publications:
- Vajkoczy, P.*, Laschinger, M.*, Engelhardt, B. (2001) α4-integrin mediates G-protein independent capture of encephalitogenic T cell blasts on endothelial VCAM-1 in spinal cord white matter microvessels. J Clin Invest. 8: 557-565. * equal contribution.
- Laschinger, M. , Vajkoczy, P., Engelhardt, B. (2002) Encephalitogenic T cells use LFA-1 during transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo. Eur. J. Immunol. 32: 3598-3606.
- Semmrich, M., Smith, A., Feterowski, C., Beer, S., Engelhardt, B., Busch, D. H., Bartsch, B., Laschinger, M., Hogg, N., Pfeffer, K., Holzmann, B. (2005) Importance of integrin LFA-1 deactivation for the generation of immune response. J. Exp. Med. 201: 1987-98.
- Hüser N., Fasan, A., Semmrich, M., Schmidbauer, P., Holzmann, B., and Laschinger, M. (2010) Intact LFA-1 de-activation promotes T cell activation and rejection of cardiac allograft. Int. Immunology 22: 35-44.
- Balkow, S., Heinz, S., Schmidbauer, P., Kolanus, W., Holzmann, B., Grabbe, S., Laschinger, M. (2010) LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T cell priming. Blood 116: 1885-1894.