Project A10 - Regulation of macrophage trafficking and function
Macrophages are important effector cells of the innate immune system and significantly contribute to the maintenance of tissue homeostasis. In this project, we aim to determine the metabolic wiring of different macrophage populations that develop at distinct stages of ontogeny and to define the role of immunometabolism for their trafficking and immune response. Therefore, we will combine macro-phage fate mapping analysis with condition gene deletion in the mouse embryo and postnatal life in models of sterile inflammation and bacterial infection. We believe that these experiments will elucidate important pathways regulating macrophage functions in development and disease.