SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project A10 (N) - Trafficking and immune response of yolk sac-derived macrophages

This project started 07/2015

A significant number of macrophages derives from the yolk sac (YS) and persists independently of definitive hematopoiesis. We aim to address the trafficking of YS-derived macrophages and characterize their emergence from the YS. We will thereby define the molecular cues directing their migration into organs. Finally, we will address their function in innate immunity and infection.