SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project A12 (N) -Nucleokinesis in leukocyte trafficking

This project started 07/2019

Nuclear movement (nucleokinesis) to non-random intracellular positions is critical for cellular functions, and nucleokinesis failure is linked to human disease. However, how fast migratory cells such as leukocytes position their nucleus during trafficking is largely enigmatic. To tackle this research question, we will employ a multi-disciplinary approach, combining single-cell imaging, bioengineering, unbiased system-wide experimentation, and in vivo models for leukocyte trafficking. Thereby, this project will elucidate the molecular factors and cell biological principles of nucleokinesis in leukocyte trafficking and their involvement in homeostasis and inflammation.