SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project A02 - Role of the mAbp1 interactome for leukocyte recruitment

This project aims to decipher the molecular nature of the mAbp1 interactome and its functional impact for integrin-based neutrophil trafficking in innate immunity. By integrating studies on the molecular and cellular level as well as in vivo models using versatile live cell imaging technologies, we will investigate the interaction between mAbp1 and its binding partners Coronin 1A and HPK1 and their functional impact on neutrophil trafficking. Unraveling the molecular mechanism of this immune cell function will not only improve our immediate understanding of neutrophil biology but may provide new concepts for therapeutic intervention in acute and chronic inflammatory diseases.