SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project B01 - In vivo imaging of innate immune responses in the mouse fetus

The project intends to elucidate the development of innate immune cell function during mouse fetal ontogeny. Using several molecular targets identified during the first funding period, we will investigate their contribution in innate immune cell recruitment under various in vitro and in vivo conditions. In a second step, we will use a genetic fate mapping system to test adhesive functions of fetal neutrophils derived from primitive vs. definitive hematopoiesis. Finally, we will introduce a new in vivo mouse model to study placental and fetal infection with Listeria monocytogenes.