SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project B02 - The role of pericytes in bone marrow retention and egress of myeloid leukocytes

The central goal of this project is to determine the importance of bone marrow pericytes for systemic trafficking of myeloid leukocytes. For that, we will characterize the spatial distribution of bone marrow myeloid leukocytes in relation to pericytes under steady state and inflammatory conditions ex vivo as well as in vivo using intravital multiphoton microscopy on a cell population and single cell level. In addition, we will dissect the communication between these cell types in vitro using FACS sorting. Finally, we will evaluate the functional importance of bone marrow pericytes for systemic myeloid cell trafficking focusing on myocardial infarction.