SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project B04 (E) - Antigen- and leukocyte-trafficking events guiding effective CD8+ T lymphocyte differentiation

This project ended 06/2015

The goal of the project is to explore leukocyte-migration and antigen-trafficking patterns that guide effective cytotoxic CD8+ T lymphocyte differentiation during the immune response to infection. Using a mouse model of systemic exposure to several forms of Listeria monocytogenes (L. m.), we will examine how the quality of the developing anti-microbial CD8+ T lymphocyte responses correlate with the observed microbial antigen-handling patterns in the spleen. This project will be executed using a comprehensive combination of traditional as well as cutting-edge technologies including two-photon intravital microscopy.