SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Dr. rer. nat. Ralph Thomas Böttcher


Project A05


Max-Planck-Institut für Biochemie

Am Klopferspitz 18
82152 Martinsried

Phone: +49 89 8578-2849
Fax: +49 89 8578-2424

10 most relevant publications:

1. Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT. (2018) LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. J Cell Sci. 131:jcs218214.

2. Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R. (2017) Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading. J Cell Biol. 216:3785-98.

3. Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Böttcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos Y Schnitzler M, Pincus Z, Iannacone M, Haas R, Wanner G, Lauber K, Sixt M, Massberg S. (2017) Migrating platelets are mechano-scavengers that collect and bundle bacteria. Cell. 171:1368-82.

4. Mana G, Clapero F, Panieri E, Panero V, Böttcher RT, Tseng HY, Saltarin F, Astanina E, Wolanska KI, Morgan MR, Humphries MJ, Santoro MM, Serini G, Valdembri D. (2016) PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vas-cular morphogenesis. Nat Commun. 7:13546.

5. Theodosiou M, Widmaier M, Böttcher RT, Rognoni E, Veelders M, Bharadwaj M, Lambacher A, Austen K, Müller DJ, Zent R, Fässler R. (2016) Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. Elife. 5:e10130.

6. Tseng HY, Thorausch N, Ziegler T, Meves A, Fässler R, Böttcher RT. (2014) Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability. J Mol Biol. 426:3180-94.

7. Rognoni E, Widmaier M, Jakobson M, Ruppert R, Ussar S, Katsougkri D, Böttcher RT, Lai-Cheong JE, Rifkin DB, McGrath JA, Fässler R. (2014) Kindlin-1 controls Wnt and TGF-beta availability to regulate cutaneous stem cell proliferation. Nat Med. 20:350-9.

8. Böttcher RT*, Stremmel C*, Meves A, Meyer H, Widmaier M, Tseng HY, Fässler R. (2012) Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the β1-integrin tail. Nat Cell Biol. 14:584-92. *contributed equally

9. Böttcher RT, Wiesner S, Braun A, Wimmer R, Berna A, Elad N, Medalia O, Pfeifer A, Aszodi A, Costell M, Fässler R. (2009) Profilin 1 is required for abscission during late cytokinesis of chondrocytes. EMBO J. 28:1157-69.

10. Böttcher RT, Pollet N, Delius H, Niehrs C. (2004) The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling. Nat Cell Biol. 6:38-44.