SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Prof. Dr. rer. nat. Rainer Haas


Project B05


Max von Pettenkofer-Institut

LMU München
Pettenkoferstr. 9a
80336 München

Phone: +49 89 2180 72855
Fax: +49 89 2180 72802

10 most relevant publications:

1. Königer V, Holsten L, Harrison U, Busch B, Loell E, Zhao Q, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg EJ, Zimmermann W, Fischer W, Hauck CR, Haas R. (2016) Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat Microbiol. 2:16188.

2. Kaplan-Türköz B, Jiménez-Soto L, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R*, Terradot L*. (2012) Structural insights into Helicobacter pylori oncoprotein CagA interaction with beta1 integrin. Proc Natl Acad Sci U S A. 109:14640-5. *contributed equally

3. Sewald X, Jiménez-Soto L, Haas R. (2011) PKC-dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes. Cell Microbiol. 13:482-96.

4. Fischer W, Windhager L, Rohrer S, Zeiller M, Karnholz A, Hoffmann R, Zimmer R, Haas R. (2010) Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38:6089-101.

5. Jiménez-Soto LF, Kutter S, Sewald X, Ertl C, Weiss E, Kapp U, Rohde M, Pirch T, Jung K, Retta SF, Terradot L, Fischer W, Haas R. (2009) Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. PLoS Pathog. 5:e1000684.

6. Sewald X, Gebert-Vogl B, Prassl S, Barwig I, Weiss E, Fabbri M, Osicka R, Schiemann M, Busch DH, Semmrich M, Holzmann B, Sebo P, Haas R. (2008) Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin. Cell Host Microbe. 3:20-9.

7. Rieder G, Merchant JL, Haas R. (2005) Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology. 128:1229-42.

8. Aras RA, Fischer W, Perez-Perez GI, Crosatti M, Ando T, Haas R, Blaser MJ. (2003) Plasticity of repetitive DNA sequences within a bacterial (Type IV) secretion system component. J Exp Med. 198:1349-60.

9. Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R. (2003) Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science. 301:1099-102.

10. Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. (2000) Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science. 287:1497-500.