SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Prof. Dr. rer .nat. Felix Meissner


Project A13 (N)


Institute of Innate Immunity
University Hospital Bonn

Biomedical Center (BMZ2)
Building 12, 2G
Venusberg-Campus 1
53127 Bonn

Phone: +49 228 287 51210

10 most relevant publications:

1. Kveler K, Starosvetsky E, Ziv-Kenet A, Kalugny Y, Gorelik Y, Shalev-Malul G, Aizenbud-Reshef N, Dubovik T, Briller M, Campbell J, Rieckmann JC, Asbeh N, Rimar D, Meissner F, Wiser J, Shen-Orr SS. (2018) Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed. Nat Biotechnol. 36:651-59.

2. Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E. (2018) The chaperone UNC93B1 regulates Toll-like receptor stability independently of endosomal TLR transport. Immunity. 48:911-22.e7.

3. Virreira Winter S, Meier F, Wichmann C, Cox J, Mann M, Meissner F. (2018) EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification. Nat Methods. 15:527-30.

4. Rieckmann JC, Geiger R, Hornburg D, Wolf T, Kveler K, Jarrossay D, Sallusto F, Shen-Orr SS, Lanzavecchia A, Mann M, Meissner F. (2017) Social network architecture of human immune cells unveiled by quantitative proteomics. Nat Immunol. 18:583-93.

5. Gerold G, Meissner F, Bruening J, Welsch K, Perin Paula M, Baumert Thomas F, Vondran Florian W, Kaderali L, Marcotrigiano J, Khan Abdul G, Mann M, Rice Charles M, Pietschmann T. (2015) Quantitative proteomics identifies serum response factor binding protein 1 as a host factor for Hepatitis C virus entry. Cell Rep. 12:864-78.

6. Meissner F, Mann M. (2014) Quantitative shotgun proteomics: considerations for a high-quality workflow in immunology. Nat Immunol. 15:112-17. (Commentary)

7. Meissner F, Scheltema RA, Mollenkopf HJ, Mann M. (2013) Direct proteomic quantifica-tion of the secretome of activated immune cells. Science. 340:475-8.

8. Meissner F, Molawi K, Zychlinsky A. (2010a) Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis. Proc Natl Acad Sci U S A. 107:13046-50.

9. Meissner F, Seger RA, Moshous D, Fischer A, Reichenbach J, Zychlinsky A. (2010b) Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. Blood. 116:1570-3.

10. Meissner F, Molawi K, Zychlinsky A. (2008) Superoxide dismutase 1 regulates caspase-1 and endotoxic shock. Nat Immunol. 9:866-72.