SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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PD Dr. rer. nat. Markus Moser


Projects A01 & MGK


Max-Planck-Institut für Biochemie

Am Klopferspitz 18
82152 Martinsried

Phone: +49 89 8578-2440
Fax: +49 89 8578-2422

10 most relevant publications:

1. Zhu L, Yang J, Bromberger T, Holly A, Lu F, Liu H, Sun K, Klapproth S, Hirbawi J, Byzova TV, Plow EF, Moser M*, Qin J*. (2017) Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation. Nat Commun. 8:1744. *both corresponding authors

2. Klapproth S, Moretti FA, Zeiler M, Ruppert R, Breithaupt U, Mueller S, Haas R, Mann M, Sperandio M, Fässler R, Moser M. (2015) Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice. Blood. 126:2592-600.

3. Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M. (2015) Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice. Blood. 126:2704-12.

4. Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu WH, Schulz AS, Oostendorp RA, Massberg S, Fässler R. (2015) Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells. J Exp Med. 212:1415-32.

5. Petzold T, Ruppert R, Pandey D, Barocke V, Meyer H, Lorenz M, Zhang L, Siess W, Massberg S, Moser M. (2013) β1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse. Blood. 122:2723-31.

6. Schmidt S, Nakchbandi I, Ruppert R, Kawelke N, Hess MW, Pfaller K, Jurdic P, Fässler R, Moser M. (2011) Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol. 192:883-97.

7. Moser M, Legate KR, Zent R, Fässler R. (2009) The tail of integrins, talin, and kindlins. Science. 324:895-9. (Review)

8. Moser M, Bauer M, Schmid S, Ruppert R, Schmidt S, Sixt M, Wang HV, Sperandio M, Fässler R. (2009) Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med. 15:300-5.

9. Moser M, Nieswandt B, Ussar S, Pozgajova M, Fässler R. (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med. 14:325-30.

10. Krüger M*, Moser M*, Ussar S, Thievessen I, Luber CA, Forner F, Schmidt S, Zanivan S, Fässler R, Mann M. (2008) SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function. Cell. 134:353-64. *contributed equally