SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease
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Univ.-Prof. Dr. Dr. med. Oliver Söhnlein

Responsibilities

Project B08

Contact

Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten

LMU München
Pettenkoferstraße 9
80336 München

Phone: +49 89 4400-54677
Fax: +49 89 4400-54352

10 most relevant publications:

1. Paulin N, Viola JR, Maas SL, de Jong R, Fernandes-Alnemri T, Weber C, Drechsler M*, Döring Y*, Soehnlein O*. (2018) Double-strand DNA sensing Aim2 inflammasome regulates atherosclerotic plaque vulnerability. Circulation. 138:321-23. (Research Letter) *contributed equally

2. Winter C, Silvestre-Roig C, Ortega-Gomez A, Lemnitzer P, Poelman H, Schumski A, Winter J, Drechsler M, de Jong R, Immler R, Sperandio M, Hristov M, Zeller T, Nicolaes GAF, Weber C, Viola JR, Hidalgo A, Scheiermann C, Soehnlein O. (2018) Chrono-pharmacological targeting of the CCL2-CCR2 axis ameliorates atherosclerosis. Cell Metab. 28:175-82 e5.

3. Soehnlein O, Steffens S, Hidalgo A, Weber C. (2017) Neutrophils as protagonists and targets in chronic inflammation. Nat Rev Immunol. 17:248-61. (Review)

4. Ortega-Gomez A, Salvermoser M, Rossaint J, Pick R, Brauner J, Lemnitzer P, Tilgner J, de Jong RJ, Megens RTA, Jamasbi J, Döring Y, Pham CT, Scheiermann C, Siess W, Drechsler M, Weber C, Grommes J, Zarbock A, Walzog B, Soehnlein O. (2016) Cathepsin G controls arterial but not venular myeloid cell recruitment. Circulation. 134:1176-88.

5. Viola JR, Lemnitzer P, Jansen Y, Csaba G, Winter C, Neideck C, Silvestre-Roig C, Dittmar G, Döring Y, Drechsler M, Weber C, Zimmer R, Cenac N, Soehnlein O. (2016) Resolving lipid mediators Maresin 1 and Resolvin D2 prevent atheroprogression in mice. Circ Res. 119:1030-8.

6. Alard J-E, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RTA, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D’Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GAF, Weber C, Soehnlein O. (2015) Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci Transl Med. 7:317ra196.

7. Drechsler M, de Jong R, Rossaint J, Viola JR, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Döring Y, Zarbock A, Soehnlein O. (2015) Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res. 116:827-35.

8. Soehnlein O, Wantha S, Simsekyilmaz S, Doring Y, Megens RT, Mause SF, Drechsler M, Smeets R, Weinandy S, Schreiber F, Gries T, Jockenhoevel S, Moller M, Vijayan S, van Zandvoort MA, Agerberth B, Pham CT, Gallo RL, Hackeng TM, Liehn EA, Zernecke A, Klee D, Weber C. (2011) Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med. 3:103ra98.

9. Soehnlein O, Lindbom L. (2010) Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol. 10:427-39. (Review)

10. Drechsler M, Megens RT, van Zandvoort M, Weber C, Soehnlein O. (2010) Hyper-lipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation. 122:1837-45.


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