SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project A01 - Role of kindlin-3 in hematopoietic cells in vivo

In the project, we will investigate the expression and role of Kindlin-3 during early hematopoiesis and we will study the dynamic distribution of Kindlin-3 during leukocyte trafficking. Expression of the three Kindlin homologs in blood cells will elucidate putative functional differences in their ability to regulate blood cell integrins. These studies will employ histological and various imaging techniques in vitro and in vivo, combined with FACS analyses and state of the art biochemical methods to further characterize to role of Kindlin-3 during blood cell integrin regulation.