SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project A13 (N) -Functional proteomics dissection of chemotactic protein diversity

This project started 07/2019

Chemotactic protein activity is regulated at multiple levels, including post-translational modifications. In this project, we will test the hypothesis that divergent paracrine activities arise from differentially modified chemotactic protein variants (proteoforms) by combining proteomics discovery technologies, systems biology and functional validation approaches. Thereby, we will establish a system-level view of chemokine proteoform diversity and will generate new insights about how paracrine signals and their modifications affect cell signaling and chemotaxis during tissue homeostasis and inflammation.