SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project A04 (E) - Molecular mechanism regulating LFA-1 mediated T cell migration

This project ended 06/2015

T cell migration along (crawling) or across the vasculature into lymphoid tissue and, following infection, into sites of inflammation is regulated through a cycle of LFA-1 mediated adhesion and de-adhesion. Based on our preliminary data we postulate that LFA-1 regulates via the serine/threonine phosphatase PP1 the activity of ERM proteins and hence the cytoskeletal reorganisation that is mandatory for migration of T cells. Elucidating the pathways regulating T cell polarity and integrin dependent T cell migration will help us to mechanistically understand cell migration.