Project A05 - The role of integrin trafficking and stability for leukocyte migration
Integrins are cell adhesion receptors that are involved in various aspects of hematopoietic cell function. Integrin-mediated adhesion, migration and signaling are controlled by ligand affinity regulation and the efficient recycling of integrins through endosomes. The project will investigate the molecular mechanisms that regulate the stability and recycling of leukocyte integrins. To this end, we analyze the function of SNX17 for integrin stability in leukocytes, identify and characterize the E3 ubiquitin ligase(s) that ubiquitinate integrin tails and investigate the role of the transmembrane associations of α/β subunits for integrin activity and stability.