SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project B05 - Impact of Helicobacter pylori virulence factors and CEACAM interaction on leukocyte migration

The bacterial pathogen Helicobacter pylori infects the human stomach mucosa, causing chronic gastritis, ulceration and eventually gastric cancer. Pathogenic strains inject the bacterial oncoprotein CagA into host cells by exploiting β1 Integrin. The effects and mechanisms of H. pylori CagA injection and bacteria-induced CEACAM signaling events on leukocyte migration will be studied in vitro as well as by multi-photon intravital microscopy (MP-IVM) in the H. pylori-infected mouse stomach in vivo.