SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project B07 (E) - Modulation of immune cell trafficking by Legionella pneumophila

This project ended 06/2015

Legionella pneumophila is the causative agent of Legionnaires' disease, a severe pneumonia. The bacterium employs a type IV secretion system and more than 150 different secreted “effector proteins” to subvert host cell signaling and vesicle trafficking. This project aims to elucidate on a molecular, cellular and organismic level the impact of L. pneumophila and distinct effector proteins on motility and migration of immune cells from metazoan organisms and free-living protozoa.