SFB 914 Trafficking of Immune Cells in Inflammation, Development and Disease

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Project B08 - Neutrophils and platelets cooperate in monocyte recruitment

Both neutrophils and platelets have the ability to instruct monocyte recruitment by release of pre-formed chemotactic proteins. Here we investigate the interaction of proteins of neutrophil and platelet origin and the effect of such heteromers on monocyte adhesion and recruitment. Heteromers will be characterized by surface plasmon resonance analyses and the functional relevance of heteromers is assessed by in vitro flow chamber assays and intravital epifluorescence and two photon microscopy. Finally, we will employ models of acute lung injury and myocardial infarction to test our findings in models of clinical relevance.